期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

SPARC在胃癌组织中的表达 被引量：3

Expression of SPARC in human gastric carcinoma
下载PDF
导出
摘要 目的检测SPARC在人胃癌组织中的表达,探讨其与胃癌浸润转移的关系。方法运用免疫组化S-P法检测108例胃癌和89例正常胃黏膜组织中SPARC的表达情况。结果SPARC主要表达在胃癌的间质细胞,少数表达在胃癌细胞。SPARC在胃癌组织间质细胞的阳性表达率(88·0%)显著高于正常胃黏膜组织(14·1%)(P<0·01)。肿瘤细胞SPARC表达与胃癌生物学特性及临床各病理因素均无相关性;而间质细胞SPARC的表达与胃癌的淋巴结转移及临床分期有相关性,与性别、年龄、肿瘤大小、浸润深度、远处转移均无相关性。结论SPARC在胃癌间质过度表达可能促进胃癌的转移,可作为判断胃癌生物学行为的重要指标。 Objective To investigate the expression of the secreted protein, acidic and rich in cysteine （SPARC） in human gastric carcinoma and its relationship with tumor cell invasion and metastasis. Methods The expression of SPARC was detected in 108 cases of human gastric carcinoma specimens and 89 cases of normal gastric mucosa by using streptavidin-peroxidase immunohistochemistry. Results The SPARC was expressed mainly in the stroma cells and little in cancer cells. The positive rate of SPARC in the stroma cells of gastric carcinoma was 88.0%, which was higher than that in normal tissues（ 14. 1% ） （P 〈0. 01 ）. Epithelial SPARC expression was unrelated to the biological speciality and clinical pathologic factors of gastric carcinoma. The stromal positive expression rate of SPARC was significantly related with lymph node metastasis and clinical stage, but it did not correlate with sex, age, tumor size , the depth of tumor invasion and distant metastasis. Conclusion Stromal SPARC expression in human gastric carcinoma seems to accelerate the metastasis of gastric carcinoma. SPARC is considered as an important guideline in estimating of biological speciality of gastric carcinoma.
作者 李杨 吴继锋 张红 秦蓉 王道斌
机构地区 安徽医科大学病理学教研室 安徽医科大学第一附属医院中心实验室
出处 《安徽医科大学学报》 CAS 北大核心 2006年第6期626-629,共4页 Acta Universitatis Medicinalis Anhui
关键词 胃肿瘤 免疫组织化学 肿瘤转移 stomach neoplasms immunohistochemistry neoplasm metastasis
分类号 R735.2 [医药卫生—肿瘤] R341.31 [医药卫生—基础医学]
  • 相关文献

参考文献12

  • 1Framson P E, Sage E H. SPARC and tumor growth: where the seed meets the soil? [J]. Cell Biochem,2004,92(4) : 679 -90.
  • 2Yamashita K, Upadhay S, Mimori K, et al. Clinical significance of secreted protein acidic and rich in cystein in esophageal carcinoma and its relation to carcinoma progression[ J]. Cancer,2003,97(10) : 2412 - 19.
  • 3Le Bail B, Faouzi S, Boussarie L, et al. Osteonectin/SPARC is overexpressed in human hepatocellular carcinoma [ J ]. J Pathol,1999, 189(1) : 46 - 52.
  • 4Sato N, Fukushima N, Maehara N, et al. SPARC/Osteonectin is a frequent target for aberrant methylation in pancreatic adenocarecinoma and a mediator of tumor - stromal interactions. [ J]. Oncogene, 2003,22(32) : 5021 -30.
  • 5Michael I. K, Alexandra G, Rolf A B, et al. Enhanced Expression of SPARC/Osteonectin in the tumor-associated stroma of Non-Small cell lung cancer Is correlated with markers of hypoxia/Acidity and with poor prognosis of patients[J]. Cancer Res, 2003,63(17) : 5376 -80.
  • 6Wewer U M, Albrechtsen R, Fisher S W, et al. Osteonectin/SPARC/BM- 40 in human decidua and carcinoma, tissues characterized by de novo formation of basement membrane [ J ]. Am J Pathol, 1988, 132(2): 345-55.
  • 7Maeng H Y, Song S B, Choi D K, et al. Osteonectin-expressing cells in human stomach cancer and their possible clinical significance[ J]. Cancer Lett ,2002,184( 1 ) : 117 -21.
  • 8Wang C S, Lin K H,Chen S L, et al. Overexpression of SPARC gene in human gastric carcinoma and its clinic-pathologic significance. [J]. BrJCancer, 2004,91(11): 1924-30.
  • 9Thomas R, True L D, Bassuk J A, et al. Differential expression of osteonectin/SPARC during human prostate cancer progression [ J ].Clin Cancer Res , 2000, 6(3) : 1140 -9.
  • 10Brown T J, Shaw P A, Karp X,et al. Activations of SPARC expression in reactive stroma associated with human epithelial ovarian cancer[ J]. Gynecol Oncol, 1999,75 ( 1 ) :25 - 33.

同被引文献44

  • 1车轶群,王海,齐军,郭健,刘芝华.食管鳞癌组织中SPARC蛋白表达的临床意义[J].中国肿瘤临床,2006,33(2):61-63. 被引量：12
  • 2Ling Yang.Incidence and mortality of gastric cancer in China[J].World Journal of Gastroenterology,2006,12(1):17-20. 被引量：345
  • 3Motamed K, Funk SE, Koyama H, et al. Inhibition of PDGFstimulated and matrix-mediated proliferation of human vascular smooth muscle cells by SPARC is independent of changes in cell shape or cyclin-dependent kinase inhibitors [ J]. J Cell Biochem, 2002, 84(4) :759-771.
  • 4Kato Y, Lewalle JM, Baba Y, et al. Induction of SPARC by VEGF in human vascular endothelial cells [ J ]. Biochem Biophys Res Commun, 2001,287 (2) :422-426.
  • 5Francki A, McClure TD, Brekken RA, et al. SPARC regulates TGF-betal-dependent signaling in primary glomerular mesangial cells [J]. J Cell Biochem, 2004, 91 (5) :915-925.
  • 6Wang H, Fertala A, Ratner BD, et al. Identifying the SPARC binding sites on collagen I and procollagen I by atomic force microscopy [J]. Anal Chem, 2005,77(21) :6765-6771.
  • 7Weaver MS, Sage EH, Yan Q. Absence of SPARC in lens epithelial ceils results in altered adhesion and extracellular matrix production in vitro [J]. J Cell Biochem, 2006, 97(2) :423-432.
  • 8Gagliano N, Moscheni C, Torri C, et al. Effect of resveratrol on matrix metallopreteinase-2 (MMP-2) and secreted protein acidic and rich in cysteine (SPARC) on haman cultured glioblastoma cells [J]. Biomed Pharmacother, 2005, 59(7):359-364.
  • 9Nozaki M, Sakurai E, Raisler B J, et al. Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGF-A [ J ]. J Clin Invest, 2006, 116 (2) : 422- 429.
  • 10Yan Q, Perdue N, Blake D, et al. Absence of SPARC in murine lens epithelium leads to increased deposition of laminin-1 in lens capsule [J]. Invest Ophthalmol Vis Sci, 2005, 46(12) :4652- 4660.

引证文献3

二级引证文献12

安徽医科大学学报
2006年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部