胚胎发育不良性神经上皮肿瘤12例

Dyembryoplastic Neuroepithelial Tumor Review of 12 Cases

目的探讨胚胎发育不良性神经上皮瘤(DNT)的临床特点、诊断和治疗方法。方法分析2003年1月至2005年2月,北京天坛医院收治的12例DNT患者的临床和病理资料。结果除2例以头痛发病外,其余10例患者均以癫痫为临床首发症状。MR I检查结果为T1低信号,T2高信号病灶,无水肿,无占位效应,可见脑回样或内部分隔改变。手术治疗后癫痫发作控制满意,病理学检查可见特异性胶质神经元。结论DNT手术效果良好,准确诊断对该病的治疗有重要意义。

Objective To investigate the clinical features, diagnosis and treatment of dyembryoplastic neuroepithelial tumor （DNT）. Methods 12 DNT patients who underwent operation from 2003. 1 to 2005.2 were reviewed. Results 2 patients had headache and others had epilepsy as the initial symptom. The lesions were of low intensity on T1 and of high intensity on T2, there were neither edema nor mass effect and epilepsy was well controlled after operation. Specific glioneuronal neurons were typical manifestation in pathological examination. Conclusion DNT is a beingn tumor and the surgery is curative. The correct diagnosis of DNT is of great importance in the treatment of DNT.