摘要
尼古丁是烟草中生物碱的主要成分,其生物学作用广泛。尼古丁参与影响神经系统、呼吸系统和心血管系统等重要器官的发育,并与癌症的发生有着密切的关系。尼古丁通过对细胞凋亡的调控,发挥其生物学作用。现对尼古丁调控细胞凋亡相关的各种信号通路及其分子机制进行综述。
Nicotine is a main component in tobacco, which has broad biological significance. Not only does nicotine have effect on the development of nerve, respiratory and cardiovascular systems, but has a complex interaction with carcinogenesis. By regulating apoptosis, nicotine plays an important biological role. This paper mainly reviews the signal pathways and molecular mechanisms of nicotine in apoptotic regulation.
出处
《细胞生物学杂志》
CSCD
2006年第6期827-832,共6页
Chinese Journal of Cell Biology
基金
国家自然科学基金(No.C011007)
教育部新世纪优秀人才支持计划(2004
2005)
教育部科学技术研究重点项目(No.2004.28)资助~~
关键词
尼古丁
信号途径
凋亡
nicotine
signal pathway
apoptosis
