摘要
目的探讨慢性丙型肝炎患者顺应性对IFN抗HCV治疗效果的影响。方法对聚乙二醇干扰素α-2a单药和与联合利巴韦林治疗慢性丙型肝炎的疗效与安全性的开放、多中心对照研究中患者的干扰素治疗进行回顾性研究。以持续病毒学应答作为疗效的主要评价指标,分析患者顺应性对IFN疗效的影响。结果190例患者用IFN治疗,其中未完成全部治疗而脱落的病例为63例,脱落率为33·20%。完成12周治疗的179例患者中,102例(56·98%)取得早期病毒学应答。127例完成了整个疗程,79例取得持续病毒应答,PP人群的持续病毒应答率为62·2%,ITT人群的病毒持续应答率为23·68%,两者之间差异具有统计学意义(χ2=152·5,P<0·0001)。结论患者顺应性对慢性丙型肝炎IFN治疗效果的影响较大。
Objectives The aim of this study was to evaluate the effect of obedience on IFN treatment in patients with chronic hepatitis C. Methods In this retrospective study, all patients were from a randomized, opened and multi-center clinical trial about the efficacies and safety of PEG-IFN α-2a alone or in combination with ribavifin treatment in chronic hepatitis C in China. The main parameter to evaluate the efficacy was sustained viral response （SVR） rate. The influence of obedience on IFN treatment was analyzed. Results This clinical trial enrolled 190 patients treated with IFN, but 63（33.20% ） cases could not complete their treatment course. Of 179 patients finished 12 weeks treatment, early treatment sustained virological response （SVR）, the SVR rate in PP population was 62.20 %, which was significantly higher than that （23.68 % ） in intention to treat （ITY） population （X^2 = 152.2, P 〈 0.0001 ）. Conclusions The patients＇ obedience influenced the effect of the IFN treatment obviously.
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
北大核心
2006年第4期312-314,共3页
Chinese Journal of Experimental and Clinical Virology
