TGF-β_1和COLⅢ及FN与放射性纤维化形成和发展的关系

Relationship between TGF-β_1,COLⅢ,FN and the process and development of radioation fibrosis

随着分子生物学技术的不断引入,我们认识到细胞间某些细胞因子的激活及其与细胞间的相互作用是放射性纤维化形成的关键。细胞外基质(extracellularmatrix,ECM)的产生细胞,即成纤维细胞的活化,是纤维化形成的核心环节。转化生长因子β1(transforminggrowthfactor-β1,TGF-β1)在目前的研究中与ECM积聚关系最为密切,是放射性纤维化形成的主要启始因子之一。Ⅲ型胶原蛋白(COLⅢ)和纤维连结蛋白(fibronectin,FN)是ECM的重要成份,在放射性纤维化的形成和发展中也起重要的作用。

Along with the molecular biological technology development, we realize that the key of radioation fibrosis formation is some activited cytokines and their interaction with some cells. Fibroblast is the producer of ECM, and its activation is the main step of fibrosis. In recent studies, transforming growth factor-β1（TGF-β1） is the most important cause for accumulation of ECM and one of the main initiation factors of radiation fibrosis program. COL m and FN are important ingredients of ECM, so they also play an important role in the process and development of radioation fibrosis.