肝硬化与睾酮、雌二醇相互作用关系研究现状

Current status on the interaction of testosterone and estradiol with liver cirrhosis

肝脏是睾酮、雌二醇等性激素在体内转化、降解的重要器官,但性激素并不是简单、被动地在肝内被代谢降解,其本身或代谢产物均参与肝脏疾病的发生、发展过程.肝硬化发生时可导致性激素睾酮、雌二醇代谢紊乱;相反地,性激素对肝硬化甚至肝癌的发生也有一定的影响.深入了解这一相互作用关系对于预防肝硬化的发生、探索肝硬化的治疗新途径具有重要意义.本文探讨了生理状态、病理状态下睾酮、雌二醇的表达变化,并探讨了睾酮、雌二醇对肝硬化发病的影响及其与肝硬化预后关系.

Liver acts as one of the pivotal organs that are involved in the transformation and degradation in vivo of the sex hormones, such as testosterone and estradiol. However, the sex hormones are not degraded in the liver simply and passively. They themselves and their metabolites play key roles in the occurence and development of liver diseases. There are metabolic disorders of testosterone and estradiol in the cirrhotic patients; On the contrary, sex hormones have certain influences on the occurrence of liver cirrhosis, even hepatocellular carcinoma. Comprehensive understanding of this interaction relationship is significant for liver cirrhosis both in prevention and novel treatments. In this article, we probed into the expression of both testosterone and estradiol under the physiological and pathological state, respectively, as well as＇the influences of testosterone and estradiol on the pathogenesis and prognosis of cirrhosis.