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Rho蛋白在肿瘤发生发展中的作用 被引量：2

Role of Rho GTPases in carcinogenesis and tumor progression
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摘要 Rho蛋白是参与细胞内信号转导的重要蛋白,Rho家族成员及其各自的已知下游效应分子参与调节细胞的增殖、基因表达,同时是改变细胞骨架组装、调控细胞迁移进而参与肿瘤发生发展的关键因子,具有潜在而重要的临床应用价值。 Rho GTPases are important proteins in signal transduction and control a set of essential cellular functions such as cell proliferation, gene expression,eytoskeletal dynamics,cell movement and tumor progression. Rho GTPases participate in and wgulate signalling pathways downstream of their effectots,which are the very molecules thai mediate invasiveness or metastasis of tumor cells. Rho has a potential and important value in clinical application.
作者 王德盛 晋亮 孙辰婧 窦科峰
机构地区 第四军医大学西京医院肝胆外科
出处 《国际肿瘤学杂志》 CAS 2006年第12期887-890,共4页 Journal of International Oncology
基金 国家自然科学基金(30400425)
关键词 RHO因子 肿瘤 肿瘤转移 Rho factor Neoplasms Neoplasm metastasis
分类号 R730.2 [医药卫生—肿瘤]
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参考文献20

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  • 2Jaffe AB,Hall A.Rho GTPases:biochemistry and biology.Annu Rev Cell Dev Biol,2005,21:247-269.
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同被引文献17

  • 1李家兵,唐伟.p57^(kip2)在膀胱癌的表达及意义[J].重庆医科大学学报,2004,29(6):765-768. 被引量：1
  • 2陈明流,石铮.RhoC基因与肿瘤的侵袭和转移[J].医学综述,2005,11(11):995-997. 被引量：3
  • 3Lin T, Zeng L, Liu Y, et al. Rho-ROCK-LIMK-cofilin pathway regulates shear stress activation of sterol regulatory element binding proteins [ J ]. C irc Res, 2003,92 ( 12 ) : 1296 - 304.
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  • 8Shin J Y, Kim H S, Park J, et al. Mechanism for inactivation of the KIP family eyelin dependent kinase inhibitor genes in gastric cancer ceils I J ]. Cancer Res, 2000,60 ( 2 ) :262 - 5.
  • 9Jin R J, Lho Y, Wang Y, et al. Down-regulation of p57kip2 in- duces prostate eaneerin the mouse [ J]. Cancer Res, 2008,15 (68) :3601 -8.
  • 10Yashiro M, Shinto O, Nakamura K, et al. Effects of VEGFR-3 phosphor-ylation inhibitor on lymph node metastasis in an ortho- topic diffuse-type gastric carcinoma mode 1 [ J ]. Br J Cancer, 2009,101(7) :1100 -6.

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国际肿瘤学杂志
2006年 第12期

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