细胞自噬及其在肿瘤发生过程中的作用

Autophagy and its role in carcinogenesis

细胞自噬性死亡是一种非凋亡性的程序性细胞死亡,其特征是在垂死细胞中利用自噬小体对细胞内容物进行降解。现对自噬的病理形态特征、生化改变、发生机制、分子调控、与凋亡的联系进行综述,以利于加深对细胞死亡方式的进一步认识,并介绍自噬在肿瘤发生过程中作用的研究进展。

Autophagic cell death is a kind of non-apoptotic programmed cell death. It is characterized by using autophagosome to degrade cell content in dying cells. This article reviews the pathologic morphology characteristics, biochemical change, molecular mechanism of autophagy and its relation to apoptosis to further understand the cell death modes and introduces the research progress of its role in carcinogenesis.