玉米ACEI活性肽体内降血压功能试验研究

Antihypertensive Effect in vivo of Zein ACEI Peptides

采用灌胃和静脉注射的方法,考察了玉米ACEI活性肽对SHR大鼠的降血压作用。结果表明,经灌胃玉米ACEI活性肽后,SHR大鼠的血压明显下降且平稳,高剂量组(450mg/kg.bw)降压效果与药物Captopril(5mg/kg.bw)相当。静脉注射效果远远好于灌胃,可能肠道酶对玉米ACEI活性肽有一定的分解作用。

Effect of ACEI peptides of zein on spontaneously hypertensive rat （SHR） blood pressure was studied by way of ig and iv. The following are the results： Blood pressure of SHR decreases obviously and steadily after fed with antihypertensive peptides in a single oral and successively administration, respectively. The effect of high dosage （450mg/kg · bw） peptides is the same as that of medicament Captopril （dosage 5mg/kg · bw）. The antihypertensive activity of mainline is much better than oral adnlinistration. Tile intestinal enzyme could degrade the peptides partly.