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增殖型糖尿病视网膜病变与肿瘤坏死因子β基因多态性的相关性研究 被引量：1

The correlation between proliferative diabetic retinopathy(PDR) and polymorphism of TNF-β
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摘要 目的探讨肿瘤坏死因子β(TNF-β)基因多态性和增殖型糖尿病视网膜病变(PDR)之间的相关性。方法用PCR-RFLP方法检测、比较各组间等位基因频率的分布。结果PDR组TNF-β2的基因频率较单纯型糖尿病视网膜病变组增高,差别有统计学意义(P<0.05)。结论TNF-β基因多态性可能是PDR的一个遗传易感标记。 Objective To investigate the correlation between TNF-β Nco Ⅰpolymorphism and PDR. Methods PCR RFLP analysis of frequencies of allele in each group. Results The frequency of allele TNF-β2 was significantly higher in patients with PDR than that without PDR（P〈0.05）. Conclusion This polymorphism of TNF-β can be served as a susceptible genetic marker of PDR.
作者 于强 王化峰
机构地区 中山大学中山眼科中心
出处 《中国糖尿病杂志》 CAS CSCD 北大核心 2006年第6期420-421,共2页 Chinese Journal of Diabetes
基金 广东省科技计划资助项目(2002C30501)
关键词 糖尿病视网膜病 基因 肿瘤坏死因子 Diabetic retinopathy Gene Tumor necrosis factor
分类号 R587.2 [医药卫生—内分泌]
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参考文献3

  • 1Katerina K,Muzik J,Karaskova J.et al.Duration of Non-Insulin-Dependent Diabetes mellitus and the TNF-β NcoⅠ geneotype as predictive factors in proliferative diabetic retinopathy.Ophthalmologica,2001,215:294-298.
  • 2陈盛强,刘利东,邓维意,陈柏铭.广东汉族人TNF多态性[J].遗传,2001,23(4):347-348. 被引量：2
  • 3Goldstein R,Sengar DP.Comparative studies of the major histocompoatibilty complex in French Canadian and non-French Canadian with SLE.Arthritis Rheum,1993,36:1121-1127.

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同被引文献9

  • 1Kempen J H,OColmain B J,Leske M C,et al.Theprevalence of diabetic retinopathy among adults in the United States[J].Arch Ophthalmol,2004,122(4):552-563.
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  • 9Khazaee M H,Tavakol Afshari J,Khazaee B,et al.HLADQB1 subtypes predict diabetic retinopathy in patients with type I diabetes mellitus[J].Eur J Ophthalmol,2009,19(4):638-645.

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中国糖尿病杂志
2006年 第6期

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