摘要
目的探讨肿瘤坏死因子β(TNF-β)基因多态性和增殖型糖尿病视网膜病变(PDR)之间的相关性。方法用PCR-RFLP方法检测、比较各组间等位基因频率的分布。结果PDR组TNF-β2的基因频率较单纯型糖尿病视网膜病变组增高,差别有统计学意义(P<0.05)。结论TNF-β基因多态性可能是PDR的一个遗传易感标记。
Objective To investigate the correlation between TNF-β Nco Ⅰpolymorphism and PDR. Methods PCR RFLP analysis of frequencies of allele in each group. Results The frequency of allele TNF-β2 was significantly higher in patients with PDR than that without PDR(P〈0.05). Conclusion This polymorphism of TNF-β can be served as a susceptible genetic marker of PDR.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2006年第6期420-421,共2页
Chinese Journal of Diabetes
基金
广东省科技计划资助项目(2002C30501)