中青年肾移植者合用环孢素A和百令胶囊后血生化指标的三维图像

Analysis of 3-dimensional images of blood analytic values in kidney transplantation recipients with cyclosporine and corbrin

目的:研究中青年肾移植者合用环孢素与百令胶囊后全血环孢素A的浓度变化及对血6项生化指标的影响。方法:将40～59岁的中年患者(n=219)和小于40岁的青年患者(n=145)的合用环孢素A与百令胶囊天数、百令胶囊剂量、全血环孢素A浓度、红细胞计数(RBC)、血红蛋白(Hb)、白蛋白(ALB)、总胆固醇(TC)、三酰甘油(TG)与血糖(Glu)共9项指标分为3组:(合用药物天数+全血环孢素A浓度+百令胶囊剂量)组,(RBC+Hb+ ALB)组,(TC+TG+Glu)组,采用MATLAB 7．0软件分别绘制中年和青年组的三维图像,分析图像特征并对比分析中年组与青年组的图像异同。结果:三维图像显示出各项指标间存在内在关系与个体差异。结论:环孢素与百令胶囊的合用天数对中、青年肾移植患者的血6项生化指标有不同影响。

Objective： To investigate the correlation of blood-cyclosporine A （CsA） and other blood biochemical tests in kidney transplantation recipients with combination of CsA with corbrin. Methods： A retrospective analysis was used to dispose the 3-D correlationship of blood biochemical, hematological and dosing status in patients at age of 40 - 59 （ n = 219） and below 40 （ n = 145 ）, who were treated with CsA and corbrin post kidney transplantation, by a MATLAB 7.0 program. The analytic categories were divided into three groups ： dosing status factor including total days of combination therapy, blood CsA concentration and dosage of corbrin administered, blood hematology factor including RBC, Hb and albumin, and blood biochemical factor including blood sugar,total cholesterol and triglycerides. The 3D images of the two age groups were compared. Results： The 3-D images showed the internal correlation and individual difference of blood factors and dosing factor in patients with combination therapy post kidney transplantation. Conclusion： The combination of CsA with corbrin impacted the blood factors in patients with kidney transplantation.