冠心病患者颈动脉硬化及其血小板CD62P的观察研究

Research of carotid arteriosclerosis and platelet-CD62P in patients with coronary heart disease

目的观察冠心病患者颈动脉硬化病变及其血小板CD62P水平变化,探讨诊断冠心病敏感的预测指标及明确冠心病患者相关检测指标的变化规律,为冠心病的预防、诊断和治疗提供理论指导。方法使用彩色多普勒超声诊断仪及流式细胞仪检测26例正常老年对照组、35例稳定型心绞痛及30例急性冠脉综合征(ACS)患者颈动脉内膜-中层厚度(IMT)、斑块形成情况及外周血血小板CD62P阳性率,同时记录血压、血糖、血脂等指标。结果稳定型心绞痛、ACS2组IMT较正常对照组显著增厚(分别为P<0.05、P<0.01),ACS组CD62P较其他2组显著增高(P<0.01),冠心病患者血压、血糖增高,高密度脂蛋白胆固醇降低。结论彩色多普勒超声颈动脉探查、结合血小板CD62P检测对冠心病预防、诊断及监测有重要临床意义。

Objective To investigate the susceptive index to forecast coronary heart disease（CHD） ,identify variation of correlated character and provide theory guidance for the prevention , diagnosis and therapy about CHD. Methods All patients were divided into three groups ： 26 of normal control, 35 of stable angina and 30 of acute coronary syndrome （ACS）. IMT and plaques of carotid artery were detected with the color Doppler uhrasonography, and peripheral blood platelet-CD62P was detected with flow cytometry. The blood pressure, serum glucose and blood fat of patients were determined at the same time. Results Compared with the normal control, the IMT level were significantly higher in patients with stable angina and ACS（ P 〈 0. 05 and P 〈 0. 01 ） , and the percentages of platelet-CD62P positive increased significantly in the patients of ACS（P〈 0. 01 ） . The blood pressure, serum glucose in patients with CHD were higher and the high density lipoprotein-cholesterol was lower than those of the normal control. Conclusions The color Doppler uhrasonography examination of carotid artery and the detection of CD62P expression of platelet have important clinical meaning, which helps prevent, diagnose and monitor CHD.