乌拉地尔预防气管插管所致心血管反应的效果观察

Clinical effects of preventing circulating response during endotracheal indubation by urapidil

[背景]观察乌拉地尔预防气管插管所致心血管反应的效果.[病例报告]选择需行全身麻醉的手术病人60例,随机分为对照组和观察组,每组各为30例.麻醉诱导期给对照组及观察组患者依次静脉注射咪唑安定0.1 mg/kg、芬太尼2.0μg/kg、依托咪酯0.4 mg/kg及万可松0.14 mg/kg.在气管内插管前30 s给观察组患者静脉推注乌拉地尔0.6 mg/kg,观察并记录麻醉诱导前、插管时、插管后10 min时两组患者血压及心率的变化.结果见插管时对照组患者血压明显高于诱导前,而观察组患者则明显低于诱导前.[讨论]麻醉诱导期气管插管前预防性静脉推注给予乌拉地尔可有效地抑制气管插管所引发的心血管反应,可避免因气管插管所致的麻醉意外发生.

BACKGROUND To observe the effects of the preventing circulating response during endotracheal intubation by urapidil. CASE REPORTS 60 patients scheduled for elective surgery under general anesthesia were divided into control group and observation group with 30 cases each. Anesthesia was induced with midazolam 0.1 mg/kg, fentanyl 2.0 μg/kg, etomidate 0.4 mg/kg, vecuronium bromide 0.14 mg/kg during induction. In observation group, urapidil 0.6 mg/kg was injected intravenously 30 s ago before endotracheal intubation. BP, HR were continuously monitored at induction, intubation, and intubation 10 rain late respectively. There were significantly higher on BP after endotracheal intubation than before induction in control group. DISCUSSION The circulating response can effectively provide by urapidil during anesthesia endotracheal intubation induction