胰岛素抵抗对认知功能影响的临床观察(附60例分析)

Clinical analysis of the impact of insulin resistance on cognitive function:With 60 clinical cases analysis

目的探讨胰岛素抵抗对认知功能的影响。方法将入组年龄界定在60～70岁,随机抽取胰岛素抵抗患者30例,作为胰岛素抵抗组;随机抽取已进行胰岛素注射1个月以上的患者30例,作为胰岛素注射治疗组。对两组病例进行简易智能状态检查法(MMSE)评分;按照文化程度确定MMSE的阳性标准:文盲≤19分,小学≤22分,初中或以上≤26分;对两组的MMSE结果进行统计分析。结果胰岛素抵抗组的认知功能障碍发病率高于胰岛素注射治疗组(P<0.05)。结论胰岛素抵抗可能是认知功能障碍的危险因素之一。防治胰岛素抵抗是预防患者发生认知功能障碍的临床措施之一。

Objective Discussing the impact of insulin resistance on cognitive function. Methods The age group was set between 60 and 70 years old. 30 cases out of random selection with insulin resistance were grouped as insulin-resistant group： another 30 cases out of random selection with insulin injection over 1 month were grouped as insulin-injeetion-therapy group. Mini Mental State Examinations （MMSE） were conducted in the two groups of patients respectively. The MMSE positive standard was set according to intellectual levels： illiteracy≤19 points, primary school≤22 points, junior school or above≤26 points. The MMSE results of two groups were then analyzed respective. Results The incidence of obstruction against cognitive function is higher in the insulin resistance group than that in the insulin-injection-therapy group （P〈0.05）. Conclusion The insulin resistance may be one of hazard obstructions against cognitive function. The prevention and cure of insulin resistance is one of the clinical methods that prevent the obstruction of cognitive function.