培哚普利加黄芪注射液治疗难治性心力衰竭疗效观察

Observation of therapeutic effect of perindoprol and milkvetch injection in treatingobstinate congestive heart failure

目的观察培哚普利(Perindoprol)加黄芪注射液(Milkvetch Injection,MI)治疗充血性心力衰竭(CHF)的疗效。方法器质性心脏病并发CHF心功能IV级(NYHA分级标准)。经2周足量的强心甙、利尿剂、β-受体阻滞剂治疗后心功能无明显改善者64例。随机分成治疗组32例,在常规治疗基础上加培哚普利加MI静脉滴注2周;对照组32例用米力农静脉滴注2周,治疗前后作心肌酶谱、血浆肌钙蛋白I(cTnI)测定,彩色超声心动图测定心功能。结果两组与治疗前比较心功能均有显著改善(P<0.01),两组疗效差异无显著性(P>0.05);治疗后血磷酸肌酸激酶同工酶(CK-MB)及cTnI浓度均有改善,但以治疗组为显著(P<0.01),对照组不明显(P>0.05)。在治疗过程中两组均未见明显不良反应。结论在难治性心力衰竭患者中培哚普利加MI有助于心功能的改善。

Objective To observe the therapeutic effect of perindopml and milkvetch injection （MI） in treating obstinate Congestive heart failure（OCHF）. Methods The patients with congestive heart failure were treated by cardiac glycoside, diuresis, beta blockers for two weeks. 64 patients whose cardiac functions hadn＇t been improved were divided into two groups by randomized grouping method. The patients of control group were treated with milrinone injection for two weeks. The patients of therapeutic group were treated with MI for two weeks. The changes in serum cardiac troponin Ⅰ （cTnI）, creatine kinase isoenzyme （CK-MB） and cardiac function were monitored. Results The cardiac functions of two groups were remarkably improved （ P 〈 0.01）. The difference between two groups wasn＇ t remarkable （ P 〉 0.05 ）. The densities of CK-MB and cTnI in two groups were reduced. The change of the therapeutic group was remarkable （ P 〈 0.01 ）, and the change of conservative group wasn＇t remarkable （ P 〉0.05 ）. No serious adverse reaction was found in the therapeutic course. Conclusion Perindopml and MI are helpful to improving the cardiac function in CCHF patients.