微波辐射下2-氨基苯并咪唑的合成与表征

Synthesis and characteristics of 2-aminobenzimidazole under microwave irradiation

在微波辐射下,以NaOH为催化剂,由氨基氰和邻苯二胺合成2-氨基苯并咪唑,通过正交实验确定了最优化工艺条件:微波辐射时间为165 min,微波功率为162 W,反应物物质的量比为1∶1.2。产物的收率为83%,其结构经过数字熔点仪、红外光谱仪和1HNMR表征确认。

2-Aminobenzimidazole synthesized from phenylcnediamine and cyanamide on the sodium hydroxide catalyst under microwave irradiation. The results of orthogonal experiments showed that the optimum conditions was as follows：irradiation time 165 min, microwave power 162 W, molar ratio of raw materials 1 ： 1.2, and the overall yield reached 83 %. The structures of the compounds were confirmed by melting point determination,lR and 1HNMR.