N－甲基－9－氮杂螺［5．5］十一烷－3－酮的合成

SYNTHESIS OF N-METHYL-9-AZASPIRO[5.5]UNDECANE-3-ONE

报导了新杂螺化合物９－氧杂螺［５．５］十一烷－３－酮的合成．即以Ｎ－甲基－４－唬啶酮为原料，与对甲苯磺酰甲胩反应，转化为Ｎ－甲基－个吸啶基甲腈２，２经水解、酯化、还原及氧化生成了Ｎ－甲基－个哌啶基甲醛６，６与甲基乙烯酮在的催化作用下经迈克尔加成反应得到了Ｎ甲基－９－氢杂螺［５．５］十一烯－３－酮７，最后加氢生成了目标物．

A new important spiroheterocycles-compound,9-methyl-9-azaspiro[5.5]nudecane-3-one was synthesized.Firstly N-methylpiperidin-4-carbonitrile 2 was obtained from Nmethyl-4-piperidone and TOSMIC(Tosyl methylisocyanid).The hydrolysls、esterifination、reducktion and oxidation of the 2 produced N-methylpiperidine-4-formaldehyde 6.Furthermore,under the condition of the Michael addition the reaction of 6 with methyl vinyl ketone leads to the formation of N-methyl-9-azasPiro[5.5]undec-1-en-3-one 7.Finally,N-methyl-9-azaspiro[5.5]undecan-3-one 8 was obtained in virtue of the hydrogenation.