摘要
目的探讨雌激素受体(ER)、孕激素受体(PR)和bcl-2在子宫腺肌症中异位和在位内膜的表达及意义。方法用免疫组化EnVision法检测40例子宫腺肌症在位子宫内膜和肌间异位内膜ER、PR和bcl-2的表达情况。结果在位和异位子宫内膜组织中均有ER、PR和bcl-2的阳性表达。其中腺上皮阳性表达率高于间质(P<0.05),且异位内膜的腺上皮bcl-2阳性表达率高于在位组织(P<0.05);ER和PR的表达两者差异无显著性(P>0.05)。异位内膜腺体ER、PR与bcl-2表达具有相关性(P<0.01)。结论子宫腺肌症异位和在位子宫内膜组织中均有ER、PR和bcl-2的阳性表达,可能与子宫腺肌症的发生、发展有关。
Purpose To investigate the expressions of ER, PR and bcl-2 in the pathogenesis of adenomyosis uterus. Methods The expressions of ER, PR and bcl-2 in 40 cases of adenomyosis uterus were detected by immunohistochemical EnVision method. Results Both the eutopic and ectopic endometrium in 40 cases showed positive for ER, PR and bcl-2 （P 〉 0.05）. The strong positive rate in the eutopic endometrium was significantly higher than that in the stroma cells （ P 〈 0. 05 ）. The expression of bcl-2 increased significantly in ectopic endometrium was slightly than those in eutopic endometrium （ P 〈 0.05）. The expression of ER and PR had a positive correlation with the expression of bcl-2 （P 〈 0.01 ）. Conclusions ER, PR and bcl-2 may play an important roles in promoting the development of adenomyosis.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2006年第6期663-665,共3页
Chinese Journal of Clinical and Experimental Pathology
基金
浙江省温州市科技局医药卫生科技计划项目(Y2005A179)
