心血管力学生物学研究的新进展

Recent advances in cardiovascular mechanobiology

力学生物学研究力学环境对生物体健康、疾病或损伤的影响,研究生物体的力学信号感受和响应机制,阐明机体的力学过程与生物学过程如生长、重建、适应性变化和修复等之间的相互关系,从而发展有疗效的或有诊断意义的新技术。本刊报道了国内心血管力学生物学研究的一些新进展。心血管力学生物学探讨血管的“应力-生长”关系,阐明力学因素如何产生生物学效应而导致血管重建;基于心血管系统建模与定量分析,建立精确规范的心血管功能新的无创检测和分析技术。这些研究不仅对于揭示正常血液循环的生物力学机理,认识血管生长、衰老的自然规律,而且对于阐明血管疾病的发病机理以及提供诊断、治疗的一些基本原理包括心血管新型药物和新技术的研发都将有重要的理论和实际意义。

Mechanics regulates biological processes at the molecular, cellular, tissue, organ, and organism levels. The studies of mechanobiology encompass several broad research areas including the mechanical environment in health, disease, or injury, the mechanosensiUve responses and their mechanisms, the inter-relations between mechanics and biological processes such as growth, remodeling, adaption, and repair, and the discoveries that advance therapeutic and diagnostic procedures. The recent advances in cardiovascular mechanobiology in China were presented. The researches on cardiovascular mechanobiology are a study in search of principles of stress-growth in vasculature to bring out how are mechanical factors developing biological effect resulting in vascular remodeling, and the analytical and computational models based on solid mechanics, fluid mechanics, or thermomechanics, as well as new experimental methods that expand measurement capabilities and facilitate analysis for cardiovascular clinic. These studies will have very important theoretical and practical significance for understanding the mechanical mechanism of blood circulation, the nature laws of growth and senility of vasculature, expounding pathological mechanism of cardiovascular diseases, and the research and development of new medicines and technology in cardiovascular clinic.