摘要
目的探讨康容注射液降低颅内压的效果。方法由于颅脑损伤、颅内肿瘤、脑血管病等原因所致的急性颅内压升高的患者120例,随机平均分为研究组和对照组。研究组静脉快速输注20%康容注射液,对照组静脉快速输注20%甘露醇。所有患者均采用持续的颅内压监护或者定时的腰椎穿刺测定颅内压力,并同时观测药物的安全性、有效性以及可能出现的各种副作用。结果研究组中显效6例,有效18例,进步33例,无效3例;对照组中显效9例,有效15例,进步33例,无效3例。两组的总有效率均为95%(57/60),无明显差别。在用药期间和用药后研究组未发现任何与所用药品有关的局部及全身不良反应,对血象和肝肾功能无不良影响。对照组中1例患者出现急性肾功能损害。结论康容注射液具有较强的降低颅内压作用,对肝肾功能无损害,比甘露醇更适合老年或有肝肾功能损害的急性颅内压增高的病人。
Objective To explore the effect of Kangrong injection on reducing the high intracranial pressure (ICP). Methods One hundred and twenty patients with high ICP induced by brain injury, intracranial tumor and brain vascular disease were randomly divided averagely into both the experimental and control groups. Kangrong injection was rapidly infused venously in the experimental group, and mannitol injection was rapidly infused venously in the control group. The ICP in the patients of both the groups was consecuratively monitored. The possible side effects, safety and curative effects of Kangrong and mannitol were observed. Results Of 60 patients in the experimental group, 6 had excellent outcome of lowering high ICP, 18 good, 33 fair and 3 bad. Of 60 patients in the control group, 9 had excellent outcome of lowering high ICP, 15 good, 33 fair and 3 bad. The total effective rate(95%,57-60) in the experiment group was the same with that in the control group. No notable side effects were observed in the experimental group. Acute renal failure occurred in 1 patient of the control group during the administering the mannitol. Conclusions Kangrong injection can effectively reduced the high ICP produced by various diseases and it has no notable side effects. Kangrong injection was more proper for lowering high ICP in the eldly patients and the patients with the hepatic and renal function disturbance than mannitol.
出处
《中国临床神经外科杂志》
2006年第12期734-736,共3页
Chinese Journal of Clinical Neurosurgery
关键词
康容注射液
甘露醇
颅脑损伤
颅内压
Kangrong injection
Mannitol
Brain injury
Intracranial pressure