急性冠状动脉综合征患者血尿酸水平升高的意义

Implication of Increased serum uric acid level In patients with acute coronary artery syndrome

经冠状动脉造影证实急性冠状动脉综合征(ACS)患者398例和相匹配的378名健康者进入本研究。两组血尿酸均呈正态分布,ACS组血尿酸(322±107)μmol/L明显高于正常对照组(302±77) VanoL/L(P＜0．01)。ACS组中男性高尿酸血症(HUA)患病率为27．0%、女性为25．2%。ACS组空腹血糖、甘油三酯、尿素氮、肌酐、血压均明显高于对照组(均P＜0．01)。调整性别和年龄后多元逐步回归分析显示血胆固醇、尿酸、空腹血糖、平均动脉压为ACS冠状动脉狭窄的危险因素(P＜0．05或P＜0．01),HUA在ACS发病中起一定的作用。

Acute coronary artery syndrome （ACS） was confirmed by coronary arteriography in 398 patients, and 378 healthy persons served as the control group. Serum uric acid in ACS and control group showed normal distribution, and serum uric acid level in ACS group （322 ± 107 ）μ.mol/L was significantly higher than those in control group （302 ± 77 ）μmol/L （ P 〈 0.01 ）. The prevalence of hyperuricemia （HUA） was 27.0% in male patients and 25.2% in female. Systolic blood pressure, diastolic blood pressure, fasting plasma glucose, total cholesterol, triglycerides, creatinine and blood urea nitrogen in ACS group were higher than those in control group （all P 〈 0.01 ）. Multivariable analyses adjusted for age and sex indicated that raised fasting plasma glucose, total cholesterol, uric acid and mean arterial pressure were risk factors for coronary artery stenosis in ACS, and HUA played a role in the pathogenesis of ACS.