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2型糖尿病大鼠胰岛11β-类固醇脱氢酶1型的表达对β细胞功能的影响 被引量：3

Influence of islet 11β-HSD1 expression on isletβ-cell function in streptozotocin and high-fat induced diabetic rats
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摘要 建立链脲佐菌素联合高脂喂养诱导的2型糖尿病(DM)大鼠模型并进行腹腔内葡萄糖耐量试验,评价β细胞功能,RT-PCR和Western印迹结果显示2型DM模型大鼠胰岛11β-类固醇脱氢酶1型(11β-HSD1)表达明显升高,与空腹血糖水平呈正相关；与空腹胰岛素、胰岛素和血糖曲线下面积比值呈负相关；且11β-HSD1表达与Pdx1表达负相关。提示2型DM模型大鼠11β-HSD1在胰岛表达增加,扩大局部组织糖皮质激素效应,使B细胞功能受损。 Intraperitoneal glucose tolerance test was performed in the streptozotocin- and high fat-induced diabetic rats and normal rats. The results of RT-PCR and Western blot showed that the expression of 11β- hydroxysleroid dehydrogenase type 1 （ 11 β-HSD1 ） was higher in the diabetic rats than that in control and was correlated with fasting plasma glucose, insulin and AUC-I/G with respective correlation coefficient （r） of 0. 870, - 0.799, - 0. 850, suggesting that increased expression of 11 β-HSD1 appears to damage β-cell function through magnifying the local effect of glucocorticoids.
作者 张爱萍 张木勋 张建华 余毅恺
机构地区 华中科技大学同济医学院附属同济医院内分泌研究室
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2006年第6期586-587,共2页 Chinese Journal of Endocrinology and Metabolism
关键词 11β-类固醇脱氢酶1型 糖尿病 实验性 胰岛Β细胞 糖皮质激素 11 β-hydroxysteroid dehydrogenase type 1 Diabetes mellitus, experimental Islet β-cells Glueoeortieoids
分类号 R587.1 [医药卫生—内分泌]
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参考文献8

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共引文献34

同被引文献35

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中华内分泌代谢杂志
2006年 第6期

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