S-100A4与肿瘤形成、进展和转移的关系

Effect of S-100A4 on tumorigenesis,progression and metastasis

肿瘤转移是肿瘤患者死亡的基本原因。S-100A4为S-100钙离子结合蛋白超家族的成员,已经被归类为转移相关蛋白,为一种有很高预后意义的肿瘤转移潜能分子标记物。S-100A4蛋白的表达增加与多种肿瘤的预后呈负相关,如乳腺癌、胃癌、肝癌、髓母细胞瘤、胰腺癌、结肠癌、胆囊癌、膀胱癌、食管癌和非小细胞性肺癌。S-100A4的过表达能导致肿瘤细胞侵袭和运动能力的增加。现认为,S-100A4为一种由肿瘤细胞和肿瘤活化的间质细胞分泌的活性肿瘤转移调节因子。S-100A4可调节细胞周期的进展,改变细胞的黏附性和运动能力,并增加肿瘤细胞的存活能力,调节肿瘤细胞的侵袭和转移能力。

The tumor metastasis is the major cause of the death of cancer patients. S-100A4 is a member of the S100 family of calcium-binding proteins and has been categorized as a metastasis-associated protein. S-100A4 is a candidate as a molecular marker for metastatic potential with high prognostic significance. An increase in S-100A4 protein expression has been correlated with poor prognosis of patients with breast, colorectal, gallbladder, bladder, esophageal, nonsmall-cell lung, gastric, medulloblastoma, pancreatic and hepatocellular cancers. The overexpression of S-100A4 protein can induce the increase of invasion and mobility of the tumor cells. It has been considered that S-100A4 is secreted by the tumor and stroma cells as a regulator of tumor metastasis. S-100A4 can regulate the progress of cell cycle, change cell adhesion, cell mobility and increase the survival ability of the tumor cells.