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中枢神经系统非典型畸胎瘤样/横纹肌样瘤的诊断和治疗现状 被引量：8

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摘要 中枢神经系统非典型畸胎瘤样/横纹肌样瘤好发于婴幼儿后颅窝,其细胞形态学特征独特,肿瘤组织含有横纹肌样细胞、原始神经外胚层、上皮及间叶多向分化成分,染色体22q11.2上INI1肿瘤抑制基因缺失或突变是其分子生物学特征,结合影像学表现可准确诊断。AT/RT恶性度高,预后极差。目前,多采取以手术切除为主的综合治疗方法,未来研究的重点在于确定INI1功能并利用其进行有效干预性治疗。
作者 杨汉兵 陈礼刚 李定君
机构地区 泸州医学院附属医院神经外科
出处 《国际神经病学神经外科学杂志》 2006年第6期556-560,共5页 Journal of International Neurology and Neurosurgery
关键词 中枢神经系统 非典型畸胎瘤样/横纹肌样瘤 诊断 治疗
分类号 R739.4 [医药卫生—肿瘤]
  • 相关文献

参考文献19

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同被引文献68

  • 1李南云,武海燕,金行藻,李苏健,孟奎,孙桂勤.中枢神经系统非典型畸胎瘤样/横纹肌样瘤临床病理特点[J].临床与实验病理学杂志,2004,20(5):572-575. 被引量：15
  • 2王震,范钦和,虞梅宁,张伟明.中枢神经系统非典型畸胎样／横纹肌样瘤临床病理及免疫表型特征[J].中华病理学杂志,2006,35(8):458-461. 被引量：17
  • 3Louis DN, Ohgaki H, Wiestler OD, et al. The 2007 WHO classification of tumours of the central nervous system [J]. Acta Neuropathol, 2007, 114(2): 97-109.
  • 4Louis D N,Ohgaki H,Wiestler O D,et al.The 2007 WHO classification of tumours of the central nervous system[J].Acta Neuropathol,2007,114(7):972-109.
  • 5Tanizaki Y,Oka H,Utstuki S,et al.Atypical teratoid/rhabdoid tumor arising from the spinal cord-case report and review of the literature[J].Clin Neuropathol,2006,25(2):81-5.
  • 6Cheng Y C,Lirng J F,Chang F C,et al.Neuroradiological findings in atypical teratoid/rhahdoid tumor of the central nervous system[J].Acta Radiol,2005,46(1):89-96.
  • 7Judkins A R,Mauger J,Ht A,et al.Immunohistochemical analysis of hSNF5/INI1 in pediatric CNS neoplasms[J].Am J Surg Pathol,2004,28(5):644-50.
  • 8Judkins A R,Burger P C,Hamilton R L,et al.INIl protein expression distinguishes atypical teratoid/rhabdoid tumor from choroid plexus carcinoma[J].J Neuropathol Exp Neurol,2005,64(5):391-7.
  • 9Biegel J A.Molecular genetics of atypical teratoid/rhabdoid tumor[J].Neurosurg Focus,2006,20(1):11.
  • 10Janson K,Nedzi L A,David O,et al.Predisposition to atypical teratoid/rhabdoid tumor due to an inherited INI1 mutation[J].Pediatr Blood Cancer,2006,47(3):279-84.

引证文献8

二级引证文献12

国际神经病学神经外科学杂志
2006年 第6期

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