某地区健康人群谷胱甘肽硫转移酶T1基因型研究

Study on genetic polymorphism of glutathione S-transferase T1 in healthy Han and Yao population of guangdong province

目的探讨广东地区瑶族和汉族健康人群谷胱甘肽硫转移酶T1(GSTT1)基因多态性的分布。方法采用双重PCR方法检测226例瑶族和219例汉族人群GSTT1基因型。结果瑶族和汉族人群GSTT1缺失基因型频率分别为47.8%(108/226)及52.1%(114/219),二者之间差异无统计学意义(P>0.05);同民族不同性别之间、不同年龄之间差异亦无统计学意义(P>0.05)。结论广东地区瑶族和汉族人群GSTT1基因多态性分布与中国其他地区汉族人群、韩国人和日本人相似,而与美国黑人和白人显著不同。

Objective To investigate the distribution of glutathione-S-transferase T1 （ GSTT1 ） gene polymorphism in health Yao and Han nationalities of gnangdong province. Methods The genotypes of GSTT1 in 226 Yao and 219 Han people were detected by duplicate PCR technique. Results The Frequency of GSTT1 null genotype in Y ao nationality was 47.8% （ 108/226）, whereas that in Han nationality was 52.1% （114/219）. No significant difference between the frequency of these two groups was observed （ P 〉 0.05）. There were also no statistical differences between that of males and females as well as among that of different age within the same nationality （P 〉 0.05）. Conclusion The GSTT1 gene polymorphism in Yao and Han nationalities of Guangdong is similar to that in Chinese Han of other districts, Korea and Japan, but significantly different from that in America white and black.