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花生四烯酸细胞色素P450酶代谢产物的生理作用 被引量：2

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摘要 近十余年来对花生四烯酸细胞色素P450(CYP)氧化酶代谢途径及其产物的研究引起了学者们广泛的兴趣和重视,陆续发现并证实经此途径产生的花生四烯酸代谢产物有许多重要的生理和病理生理作用.
作者 王红 汪道文 陆再英
机构地区 华中科技大学同济医学院同济医院心内科
出处 《中国分子心脏病学杂志》 CAS 2002年第1期25-29,共5页 Molecular Cardiology of China
关键词 花生四烯酸代谢产物 细胞色素P450酶 病理生理作用 代谢途径 氧化酶
分类号 R33 [医药卫生—人体生理学]
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参考文献31

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  • 2[2]Harder DR, Campbe WB, et al. Role of cytochrome P450 enzymes and metabolites of arachidonic acid in the control of vascular tone. J Vasc Res. 1995 ;32:79-92.
  • 3[3]Cohen RA, Vanhoutte PM. Endothelium-dependent hyperpolarization:Beyond nitric oxide and cyclic GMP. Circulation. 1995:92: 3337-3349.
  • 4[4]Hayabuchi Y, Nakaya Y, et al. Endothelium-derived hyperpolarizing factor activates Caactivated K channels in porcine coronary artery smooth cells. J Cardiovase Pharmacol. 1998; 32: 642-649.
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  • 6[6]Ma YH, Gebremedhin D, Schwartzman ML, et al. 20-Hydroxyeicosatetraenoic acid is an endogenous vaso-constrictor of canine renal arcuate arteries. Circ Res. 1993; 72: 126-136.
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同被引文献28

  • 1王炎,王家宁,汪道文.花生四烯酸表氧化酶代谢产物EETs促内皮细胞的增殖[J].广东药学院学报,2005,21(1):53-56. 被引量：1
  • 2依巴代提.托合提,玛依努尔.吐尔逊,毛新民,苏巴提.吐尔地.罗勒水提取物对ADP、凝血酶诱导的大鼠血小板聚集的影响[J].新疆医科大学学报,2005,28(6):526-527. 被引量：8
  • 3陈涛,王中心.血管内皮功能障碍与2型糖尿病[J].医学综述,2006,12(6):376-379. 被引量：12
  • 4施东魁,胡春梅.花生四烯酸的主要作用及提取方法[J].中国中药杂志,2007,32(11):1009-1011. 被引量：30
  • 5Standl E,Schnell O.A look at the heart in diabetes melli tus : from failing to failing [ J ]. Diabetolia, 2000,43 ( 12 ) 14352-14369.
  • 6Miura H,Gutterman D D. Human coronary arteriolar dilation to arachidonic acid depends on cytochrome P450 monooxygenase and Ca^2+ activated K^+ channels [J].Circ Res, 1998,83 (5) : 501-507.
  • 7Eckman D M,Hopkins N,Mcbride C,et al.Endothelium dependent relaxation and hyperpolarization in guinea-pig coronary artery :Role of epoxyeicosatrienoic acid[J]. Br J Pharmacol, 1998,124(1 ):181-189.
  • 8Ohman C L, Weintraub N L, Vanrollins M, et al. Epoxye- icosatrienoic acids and dihydroxyeicosatrienoic acids are potent vasodilato in the canine coronary microcircula- tion [J ].Circ Res, 1998,83 (9) :932-939.
  • 9De Wit C,Wolfle S E. EDHF and gap junctions: impor- tant regulators of vascular tone within the microcircu- lation [ J ].Curr Pharm Biotechnol, 2007,8 ( 1 ): 11225.
  • 10Pfiste S E,Gauthier K M,Campbell W B.Vascular phar- macology of epoxyeicosatienoic acids [J].Adv Pharmacol, 2010,60:27-59.

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中国分子心脏病学杂志
2002年 第1期

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