荧光光谱法辨别丙二醇和二甘醇

Distinguishing Propylene Glycol from Diethylene Glycol by Fluorescence Spectrometry

以齐药二厂的假药事件为背景,对1,2-丙二醇、1,3-丙二醇和二甘醇的吸收光谱和荧光光谱进行了测量,实验结果证明光谱法不失为一种快捷有效的区分手段。在紫外吸收光谱中,可以通过最大吸光度的差异区分二甘醇和丙二醇;在一定紫外波长激励下,三种醇的荧光光谱特性均存在差异,以此可以对三种醇作出有效区分;在230nm激发下,将二甘醇和两种丙二醇分别混合,混合溶液的相对荧光强度均与两种丙二醇体积比呈线性反比关系,这在一定程度上证明了二甘醇的荧光量子效率大于两种丙二醇。

Regarding the false medicine incidents of qiqihaer second medicine factory as background, the absorption and fluorescence spectra of 1,2-propylene glycol, 1,3-propanediol and diethylene glycol were determined separately, which was proved to be a kind of fast and effective method for distinguishing between the compounds. Diethylene glycol shows a higher adsorption coefficiency in absorption spectrum,while the fluorescence intensity of mixed solution shows the linear relationship with the volume ratio of diethylene glycol,which indicates that the fluorescence quantum efficiency of diethylene glycol is larger than those of the two propylene glycols.