摘要
目的:探讨低蛋白饮食辅助α-酮酸延缓糖尿病肾病患者肾功能恶化的作用。方法:将肾功能处于失代偿期的糖尿病肾病患者分为单纯低蛋白饮食组(对照组)和低蛋白饮食辅助α-酮酸(试验组),在常规治疗的基础上,试验组给予优质蛋白0.6 g/(kg·d),并同时补充α-酮酸0.1 g/(kg·d)。对照组只给予优质蛋白0.7g/(kg·d),两组患者热量的摄入量均为30~35 kcal/(kg·d),动态观察两组患者肾功、营养状况、血脂、血糖的变化。结果:试验组患者肾功能恶化延缓,血脂、血糖、尿蛋白降低,差异有统计学意义(P<0.05~0.01),营养状态无明显受损。结论:低蛋白饮食辅助复方α-酮酸制剂具有减轻氮质血症,改善糖、脂、蛋白质代谢,减少尿蛋白排泄,延缓糖尿病肾病患者肾功恶化的作用。
Objective:To investigate the effect of α - ketoacid supplemented low - protein diet therapy on delaying chronic renal failure of patients with diabetic nephropathies. Method: 36 patients who were assigned to a low - protein diet supplemented with α - ketoacid group(test group, 21 patients) and low- protein diet group (control group, 15 patients). Based on the conventional therapy, patients in test group performed α - ketoaeid supplemented low- protein diet: hign quality protein 0.6 g/(ks · d ) supplemented a - ketoacid 0.1 g/(kg · d), patients in control group only performed low protein diet: high quality protein 0.7 g/(kg · d) .The dietary caloric intake were 30- 35 kcal/(kg · d) . The change of renal function, nutritional state, serum glucose, lipids and urinary protein were measured every month. Results: There were significant difference in renal function, serum glucose, lipids and urinary protein between two groups ( P 〈 0.05 - 0.01). While patients in test group maintaining good nutritional state. Conclusion: α - ketoacid supple- mented low - protein diet therapy may help to reduce azotemia, improve the carbohydrate, lipids and protein metabolism, decrease the urinary protein, delay the deterioration of renal function.
出处
《中国医药导刊》
2006年第6期403-405,共3页
Chinese Journal of Medicinal Guide
关键词
糖尿病肾病
营养
低蛋白饮食
Α-酮酸
diabetic nephropathy
nutrition
low - protein diet
α - ketoacid