并发2型糖尿病慢性丙型肝炎患者HCV基因型及临床特征分析

Investigation on HCV genotypes in chronic hepatitis C patient with diabetes and its clinical features

目的通过调查慢性丙型肝炎患者2型糖尿病并发率及其与所感染HCV基因型的关系,进一步证实糖尿病是否为丙型肝炎的肝外表现之一。方法采用荧光定量PCR技术和PCR-微板核酸杂交-ELASA技术对365例慢性丙型肝炎3、60例慢性乙型肝炎患者进行HBV、HCV定性、定量检测和HCV基因型分析并比较其与对照人群糖尿病并发率的差异。结果慢性丙型肝炎患者糖尿病并发率为32.60%,明显高于慢性乙型肝炎(9.70%)及对照组(8.29%)。合并糖尿病的慢性丙型肝炎患者血清ALT及TBIL水平显著高于未合并糖尿病者,且以1b型HCV的感染率为最高,占40.34%,与未合并糖尿病者相比差异显著。结论慢性丙型肝炎患者糖尿病并发率高,以1b型多见,且病情相对较重。

Objective To investigate the incidence of type 2 diehetes mellitus inspatient with chronic hepatitis C （CHC） and its relation to HCV genotypes, and comfirm diabetes is an exhepafic manifestation of CHC. Methods Sandwich hybridization micro plate essays and fluorescence quantification PCR technology were used to detect HBV-DNA,HCV-RNA and HCV genotypes respectively, 365 patients with chronic hepatitis C,360 patients with chronic hepatitis B and eontroh group were observed and the incidence of diabetes were analyzed. Results The incidence of diabetes in patient with chronic hepatitis C was 32.60%, higher than those of patients wth chronic hepatitis B （9.70%）and the control group （8.29%）.Serum levels of ALT and TBIL in hepatitis C patient with diabetes were higher than those without diabetes,Infection rate of HCV 1b in hepatitis C patient with diabetes is the highest（40.34%）, there were significant difference when compared with those without diabetes. Conclusion Incidence of diabetes mellitus in patient with chronic hepatitis C is high,especially those infected with HCV 1b,and the liver function of these patients are more severe.