α-生育酚油酸酯合成工艺研究

Study on the synthesis of α-tocopherol oleate

通过正交实验,研究了利用三乙胺作催化剂、α-生育酚和油酸酰氯合成α-生育酚油酸酯的工艺。最佳工艺为:α-生育酚与油酸酰氯的摩尔比为1∶2.5、催化剂用量为0.1mL/gα-生育酚、反应温度为45℃、反应时间为5h。α-生育酚酯化率可达54.87%。

To present the process development of α- tocopherol oleate synthesis by orthogonal design experiments in which α-tocopherol reacted with oleic chloride catalyzed by triethy lamine. The optimum conditions were as following, at 45℃, the rate of α-tocopherol and oleic chloride （mol/mol）=1：2.5, in the presence of 0.1mL/g α-tocopherol triethy lamine as catalyst, the esterification of α-tocopherol could exeed 54.87% after 5 hours of reaction.