培土生金综合治疗对慢性阻塞性肺病稳定期患者呼吸肌疲劳的影响

Clinical Study on the Effects of Strengthening Earth to Generate Metal Combined Treatment for Respiratory Muscle Fatigue of Paitients with Chronic Obstructive Pulmonary Disease in Stable Period

目的:观察培土生金法综合治疗慢性阻塞性肺病(COPD)稳定期患者呼吸肌疲劳的治疗作用,并初步探索其作用机制。方法:治疗组在常规治疗基础上予健脾益肺冲剂口服,综合疗法在常规治疗基础上予健脾益肺冲剂口服,同时隔姜灸双足三里与参麦液穴位注射双足三里交替进行,疗程2个月。结果:综合治疗组有效率为93.3%,治疗组为86.7%,均明显高于对照组56.7%;综合治疗组、治疗组患者血二氧化碳分压明显降低(P<0.05),综合治疗后患者血氧分压升高(P<0.01)。对照组治疗后除FVC外,肺功能各项指标及呼吸肌肌力指标MIP明显下降(P<0.01);综合治疗组治疗后FEV1.0%及MIP变化不显著(P>0.05);FVC、MVV有明显改善(P<0.01);综合治疗组治疗后FVC、MVV和MIP与对照组比较,差异有显著性(P<0.01)。结论:中医培土生金理论为指导,采用健脾益肺冲剂口服为主治疗COPD稳定期患者能明显缓解呼吸肌疲劳,延缓肺功能的进行性下降。

Objective： The aim of this study is to determine whether PeiTuShengJin combined treatment is of benefit in the treatment of respiratoiy muscle fatigue of paitients with COPD in stable period. Methods： Patients in treatment group received JIANPIYIFEI powder besides routine treatment. Patients in combined treatment group received JIANPIYIFEI powder combined indirect moxibustion with ginger and acupoint injection of SHENMEIYE for two months besides routine treatment. Results： The effective rate of combined treatment group was 93.3% which was significantly higher than which in placebo group （56.7%, P 〈 0.01 ）. There was no notable difference between treatment group （86.7%） and combined treatment group （P 〉 0.05）. Partial pressure of carbondioxide descended markedly in treatment group and combined treatmcnt group （P 〈 0.01）. A notable ascend of partial pressure of oxygen could be seen in combined treatment group （P 〈 0.01 ）. MIP and the most parameters of pulmonary function except FVC descended significantly in placebo group （ P 〈 0.01 ）. FVC were markedly improved in treatment group （ P 〈 0.01 ）. In combinal treatment group, FVC and MVV were markedly ameliorated. Which were higher than in placebo group （P 〈 0.01 ）. Discussion： Under the guidance of the theory of PeiTuShengJin in TCM, administration of JIANPIYIFEI powder combined indirect moxibustion with ginger and acupoint injection of SHENMEIYE appears to offer improvcment in respiratory muscle tatiguc and pulmonary function of paitients with COPD in stable period.