摘要
[目的]研究三子养亲汤平喘量效关系.[方法]建立卵蛋白(OVA)致敏小鼠哮喘的实验模型进行研究.结果三子养亲汤复方配伍中NO.3(莱菔子:紫苏子:白芥子1∶2∶1)高剂量组小鼠血清中IgE和LTC4(白三烯C4)的含量均低于生理盐水组(P<0.05),而其它配伍组小鼠血清组胺与生理盐水组均无明显差异(P>0.05).[结论]三子养亲汤中紫苏子的配伍含量高,平喘效果好.
[ Object] To study the quantitative dose-effect relationship of the antiasthmatic action of SanZiYangQinTang. [ Methods ] The mice asthma model was established with Ovalbumin challenge method. [ Results ] The serum IgE and leukotfiene C4 levels in mice of the high dose group of the NO. 3 compatible prescription of SanZhiYan- gQinTang,which were composed of the seeds of Raphanus satirus L, , the seeds of Perilla frutescens L. and the seeds ofSinapis alba L. Britt （1：2： 1） ,were more lower than those of the normal saline group （ P 〈 0. 05） and the serum histamine in mice was no significant difference between the different compatible prescription groups and the normal saline group （ P 〉 0. 05 ）. [ Conclusions ] A higher dose of the seeds Perilla frutescens L. in the compatible prescriptions will lead to the increase of antiasthmatic action.
出处
《大连大学学报》
2006年第6期56-58,66,共4页
Journal of Dalian University
基金
国家自然科学基金重大研究计划项目(90209041)
关键词
三子养亲汤
平喘
量效关系研究
SanZhiYangQinTang
antiasthmatic action
quantitative dose-effect relationship
