人参皂苷化学修饰物PM1抗肿瘤活性的研究

Study on antitumor activity of PM1 modificated from ginsenside

[目的]人参皂苷化学修饰物PM1是人参皂苷酶代谢产物M1与棕榈酸发生酯化反应形成的脂肪酸类酯化合物,通过对PM1进行药理学观察,确定其是否具有抗肿瘤活性.[方法]采用移植肿瘤动物模型,以生理盐水组、环磷酰胺组作对照,对小鼠腹腔注射进行药理学观察.[结果]PM1对小鼠肝移植肿瘤(HepA)的抑制作用与对照组比较有显著差异(P<0.001),肿瘤抑制率为49.92%.PM1对胃移植肿瘤(MFC)的抑制作用与对照组比较有显著差异(P<0.001),肿瘤抑制率为49.96%.[结论]PM1对小鼠肝肿瘤(HepA)、胃肿瘤(MFC)有明显的抑制作用.

[Objective] Chemical modificatiou substance of ginsenosides PM1, which is called fatty acids compound,can acquired from the reaction of esterification between M1 and palmitic acid. The present study is to certificate whether PM1 has the anti-tumor activity by pharmacological observation. [ Methods] Adopted animal model of transplant tumor, Mices im. PM1 were observed during pharmacological experiment. [ Results] The result suggested that PM1 has a significant inhibition on hepatic tumor（HepA） ,compared with control group （P 〈 0. 001 ）. The rate of inhibition is 49.92%. Meanwhile, PM1 has a significant inhibition on gastric tumor（MFC） ,compared with control group （ P 〈 0. 001 ）. The rate of inhibition is 49.96%. [ Conclusions ] PM1 has significant inhibitions on both hepatic tumor（HepA） and gastric tumor（MFC）.