急性胰腺炎294例病因分析

Etiological analysis of acute Pancreatitis in 294 cases

目的:探讨急性胰腺炎的病因,旨在提高对急性胰腺炎发病因素的认识。方法:回顾性分析我院自1996年1月至2005年12月的294例内外科住院急性胰腺炎患者。对其发病因素进行分析。结果:急性胰腺炎发病例数逐年增多,1996年至2000年间病例数占同期内外科住院总人数的0.43%,而2001年至2005年间则上升为0.65%,两者差异有显著性意义(P<0.05)。病因构成比为胆道疾病57.1%,酗酒13.3%,暴饮暴食11.9%,高脂血症6.1%,其他2.7%,不明原因8.8%。其中不明原因所占比例呈上升趋势。胆道疾病和不明原因相关急性胰腺炎以女性居多(P<0.05);高脂血症和酒精相关急性胰腺炎则以男性为主(P<0.05)。结论:急性胰腺炎常见病因依次为胆道疾病、酗酒、暴饮暴食和高脂血症,病毒感染可能是不明原因急性胰腺炎发病例数增加的一个因素。

Objective：To explore the etiology and pathogenesis of acute pancreatitis and to enhance the knowledge of its pathogenesis. Methods：294 patients with acute pancreatitis were admitted to our hospital from January 1996 to December 2005. We reviewed the clinical data to analyses the etiological factor of acute pancreatitis. Results：The patients of acute pancreatitis increased year by year. The morbidity of acute pancreatitis ranged from 0.43% （ 1996 - 2000） to 0.65% （ 2001 - 2005 ）, with significant differences （ P 〈 0.01 ）. 294 acute pancreatitis patients, including 168 （57.1% ） with biliary disease, 39 （ 13.3% ） with alcohol abuse, 35 （11.9） with Binge overeating, 18 （6. 1% ） with hyperlipidemia, 8 （2.7%） with other risk factors, and etiology remained unknown in 26 （8.8%）. Of all acute pancreatitis, uncommon causes cases had increased form 3.3% （ 1996 - 2000） to 11.3% （2001 ~ 2005 ）, with signifinicant differences （P 〈 0.01 ）. Biliary and uncommon cause pancreatitis were significantly associated with females while alcoholic and hyperlipidemia pancreatitis occurred predominantly in males. Conclusion ：The main causes of acute pancreatitis were biliary disease, alcohol, Binge overeating and hyperlipidemia. Virus infection may be one of the factors that lead to the increase of acute pancreatitis with etiology remained unknown.