奎硫平与氯氮平治疗精神分裂症疗效和安全性对比研究

A Comparative Study on Quetiapine and Clozapine's Effect and Safety Indexes on the Treating of Schizophrenia

目的:比较奎硫平与氯氮平治疗精神分裂症的疗效和安全性。方法:将102例符合入组标准的精神分裂症患者随机分为奎硫平组51例和氯氮平组51例,进行对比研究。在治疗前、治疗后2、4、6、8周末,采用简明精神病量表(BPRS)和药物治疗不良反应量表(TESS)评定疗效和不良反应。结果:治疗8周末,氯氮平组的显效率高于奎硫平组(Р=0.012);氯氮平组对心电图的影响比奎硫平组大,差异非常显著(P=0.007);两组对肝功能均有影响,组间差异无统计学意义;氯氮平组的其他不良反应比奎硫平组显著更多(Р=0.012)。结论:氯氮平对精神分裂症的疗效比奎硫平好,但不良反应比奎硫平更多;奎硫平对精神分裂症的疗效比氯氮平差一些,但不良反应比氯氮平更少、更轻,其安全性相对较高。

Objective： to study the treatment result and safety indexes of Quatiapine and Clozapine on the treating of Schizophrenia. Method： The researchers at first group the 102 schizophrenia cases into 51Quetiapine cases and 51 clozapine cases at random. Then the charts of BPRS and TESS are used to assess the treatment results and safety indexes of Quetiapine and Clozapine after 2,4,6,8 weeks treatment respectively. Results ： After 8 weeks＇ treatment, the results of Clozapine are far more favorable than those of Quetiap- ine （45 % to 22%, x2 = 6. 353, p = 0. 012）. However, the negative influence to cardiograph of Clozapine is strikingly greater than that of Quetiapine（ X2 =7. 351 ,P =0. 007 ）. Both the Quetiapine and Clozapine cases have unfavorable influences to liver function, whose differences have no siatistical significance. Other side - effects of Clozapine are far greater than those of Quetiapine （ x^2 = 6. 353, p = 0. 012）. Conclusion： The treatment effect of Clozapine on schizophrenia is better than that of Quetiapine. However, Clozapine has more side -effects. Quetiapine has greater safety indexes.