^(18)F^-生产条件和影响因素初探

Investigation of the Conditions and Effective Factors of ^(18)F^- Production

以TR19型回旋加速器为例,探讨了正电子核素18F-的生产条件和影响因素。结果表明,靶18O-H2O的丰度、束流强度、轰击时间是影响18F-产额的主要因素,18O-H2O的丰度越高,18F-产额越高;质子束流强度为10~35μA时,18F-产额随束流增加而增加;轰击时间为20~60 min时,18F-产额随轰击时间的延长而增加。此外,离子源和电磁场也应设置在一定的参数内,以提高18F-产额,提高工作效率。

The conditions and effective factors of ^18F^- which produced by ^18O （p, n） ^18F with TR19 cyclotron are investigated. The results show that the higher abundance of target water, the higher yield of ^18F^-when the proton beam current is 10-35 μA and the irradiation time is 20-60 min, the yield of ^18F^- is increased with the increasing of the proton beam current and irradiation time. Thus, the abundance of target water, proton beam current, irradiation time are the main factors affecting the yield of ^18F^- .