肝积合剂对肝硬化门静脉高压的影响

Effects of Ganji composition on portal hypertension associated with liver cirrhosis

目的:探讨肝积合剂对肝硬化门脉高压的影响。方法:将60例肝硬化门脉高压症患者随机分为两组,治疗组患者口服中药肝积合剂,对照组患者口服心得安,共3个月。用彩色双功能多普勒超声诊断仪测量门静脉内径、脾静脉内径、门静脉血流速度、脾静脉血流速度,采用胃镜观察食管静脉曲张部位、条数、形态、颜色及胃底有无静脉曲张。结果:肝积合剂可显著缩小肝硬化患者门静脉及脾静脉内径、加快血流速度、减少血流量。尤其在加快门静脉、脾静脉血流速度及减少血流量上与心得安比较,差异有显著性意义(P<0.05)。结论:肝积合剂对肝硬化门脉高压症有一定的防治作用。

Objective： To study the efficacy of Ganji composition on portal hypertension associated with liver cirrhosis. Methods： Sixty patients with portal hypertension associated with liver cirrhosis were divided randomly into the test group treated with Ganji composition and the control group with Propranolol. Duplex color Doppler uhrasonograghy were applied to detect the inner diameter, the blood flow velocity of portal and splenic vein, gastroscopy were applied to detect the site, number, shape, color and esophageal varicosis. Results： Ganji composition could remarkably decreased the inner diameter of portal and splenic vein, accelerated the rate of blood flow, decreased the volume of blood flow, especially could significantly accelerated the rate of blood flow and decreased the volume of blood flow of portal and splenic vein, which was remarkably better than that of Propranolo （P 〈 0. 05 ） . Condlusion： Ganji composition has certain function on the prevention and cureeffect of partal hypertension associated with liver cirrhosis.