1STRATER J, WELLISH I, RTEDL S, et al. CD95(APO-1/Fas)- mediated apoptosis in colonic epithelial cells:a possible role in ulcerative colitis [J] . Gastroenterology,1997,113(1): 160 - 167.
2YUKAWA M, IIZUKA M, HORIE Y, et al. Systemic and local evidence of increased Fas-mediated apoptosis in ulcerative Colitis[J] .Int J Colorectal Dis, 2002, 17(2):70 -76.
3D'ARGENIO G,FARRACE M G,COSENZAV, et al. Expression of apoptosis-related proteins in rat with induced colitis [J]. Int J Colorectal Dis,2004,19(5):451-460.
4SOUZA H S, TORTORI C J, CASTELOBRANCO M T, et al. Apoptosis in the intestinal of patients with inflammatory bowel disease: evidence of altered expression of FasL and perforin cytotoxic pathways [J] .Int J Colorectal Dis,2005,20(3): 277 - 286.
5ATREYA R, MUDTER J, FINOTT S, et al. Blockade of interleukin 6trans signaling suppresses T-cell resistance against apeptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo [J]. Nat Med,2000,6(5): 583 - 588,
6WITTIG B,SEITER S, SCHMIDT D S, et al. Selective upregulation of CD44 variant isoforms on peripheral blood leukocytes in patients with chronic inflammatory bowel disease and other systemic autoimmune disease [J] . Lab Invest, 1999, 79(6):747 -759.
7WITTIG B M, STALLMACH A, ZEITZ M,et al. Functional involvement of CD44 variant 7 in gut immune response [J].Pathobiology,2003 (3): 184 - 189.
8BRANNIGAN A E, O'CONNELL P R,HURLEY H, et al. Neutrophil apoptosis is delayed in patients with inflammatory bowel disease [J]. Shock, 2000, 13(5): 361 -366.
9INA K, KUSUGAMI K, HOSOKAWA T,et al. Increased mucosal production of granulocyte colony-stimulatlng factor is related to a delay in neutrophil apoptosis in inflammatory bowel disease [J] . J Gastroenterol Hepatol, 1999, 14(1): 46-53.
10VAN DEN BRANDE J M, BRAAT H,VANDEN BRINK G R, et al.Infliximab but not etanercept induce apoptosis in lamina propria T-lymphocytes from patients with Crohn'disease [J]. Gastroenterology,2003,124(7): 1774- 1785.
3Chen B J. Triptolide, a novel immunosuppressive and anti- inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F[J]. Leuk Lymphoma, 2001,42 (3) : 253-265.
4Qiu D, Kao P N. Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook F[J]. Drugs R D, 2003, 4(1):1-18.
5Yang Y, Liu Z, Tolosa E, et al. Triptolide induces apoptotic death of T lymphocyte [J]. Immunopharmacology, 1998, 40 (20) : 139- 149.
6Xu L H, Deng C S, Zhu Y Q, et al. Synergistic antitumor activity of TRAIL with doxorubicin on colon cancer cell line SW480 [J]. World J Gastroenterol, 2003, 9(6) : 1135-1139.
7Vermes I, Haanen C, Steffens-Nakken H, et al. A novel assay for apoptosis: flow cytometric detection of phosphati-dylserine express on early apoptotic cells using fluorescein labelled Annexin V[J]. J Immunol Meths, 1995,184( 1 ) : 39-51.
8Nagata S. Apoptosis by death factor [J]. Cell, 1997,88 (3) : 355- 365.
9Wajant H. The Fas signaling pathway: more than a paradigm [J]. Science, 2002,296 (5573) : 1635-1636.
