溶血磷脂酸与心血管系统
摘要
溶血磷脂酸是一种具有细胞间信号传导作用的脂类小分子物质,通过G蛋白偶联受体介导多种生物学功能,在心血管系统中具有重要作用。本文主要对LPA的合成释放与运输、G蛋白偶联受体及LPA在心血管系统的病理生理作用进行综述。
出处
《中国分子心脏病学杂志》
CAS
2006年第6期369-372,共4页
Molecular Cardiology of China
基金
国家自然科学基金(30170374)
参考文献39
-
1[1]Pages C,Simon M,Valet P,et al.Lysophosphatidic acid synthesis and release(1).Prostaglandins,2001,64:1-10.
-
2[2]Tigyi G.Physiological responses to lysophosphatidic acid and related glycero-phospholipids.Prostaglandins Other Lipid Mediat,2001,64:47-62.
-
3[3]Seewald S,Sachinidis A,Dusing R,et al.Lysophosphatidic acid and intracellular signalling in vascular smooth muscle cells.Atherosclerosis,1997,130:121-131.
-
4[4]Eichholtz T,Jalink K,Fahrenfort I,et al.The bioactive phospholipid lysophosphatidic acid is released from activated platelets.Biochem J,1993,291 (Pt 3):677-680.
-
5[5]Eder AM,Sasagawa T,Man M,et al.Constitutive and lysophosphatidic acid (LPA) -induced LPA production:role of phospholipase D and phospholipase A2.Clin Cancer Res,2000,6:2482-2491.
-
6[6]Sengnpta S,Xiao YJ,Xu Y.A novel laminin-induced LPA autocrine loop in the migration of ovarian cancer cells.Faseb J,2003,17:1570-1572.
-
7[7]le Balle F,Simon MF,Meijer S,et al.Membrane sidedness of biosynthetic pathways involved in the production of lysophosphatidic acid.Adv Enzyme Regul,1999,39:275-284.
-
8[8]Tokumura A,Majima E,Kariya Y,et al..Identification of human plasma lysophospholipase D,a lysophosphatidic acid-producing enzyme,as autotaxin,a multifunctional phosphodiesterase.J Biol Chem,2002,277:39436-39442.
-
9[9]Umezu-Goto M,Kishi Y,Taira A,et al.Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production.J Cell Biol,2002,158:227-233.
-
10[10]Tigyi G,Parrill AL.Molecular mechanisms of lysophosphatidic acid action.Prog Lipid Res,2003,42:498-526.
-
1FerroCJ,龙超良.内皮素受体拮抗剂在心血管疾病中的临床应用[J].国外医学（药学分册）,1996,23(6):347-350.
-
2颜崇平.氯沙坦治疗老年高血压的疗效及对血浆内皮素、心钠素的影响[J].重庆医学,2005,34(8):1236-1238.
-
3袁志敏,刘豫陇.血管紧张素Ⅱ受体拮抗剂临床应用近况[J].医学综述,2003,9(9):571-572. 被引量：8
-
4张永雪,陈清,马俊芬,郭卫东,吴建明.牛磺酸对原发性高血压的治疗及对内皮素的影响[J].开封医专学报,1998,17(2):13-15. 被引量：1
-
5黄芳华.中药新药一般药理学研究技术要求和常见问题分析[J].中国中药杂志,2007,32(1):82-84. 被引量：14
-
6王先梅,祝善俊.血管紧张素转换酶2基因在心血管系统中的作用[J].心血管病学进展,2005,26(3):248-251.
-
7李国春,黄新武.氯沙坦在国内应用研究进展[J].中国药师,2005,8(11):952-954. 被引量：18
-
8牟科,付翌秋,徐萍.蛋白酶体抑制剂的研究进展[J].国际药学研究杂志,2009,36(5):348-354. 被引量：4
-
9陈百泉,陈清,孙玉生,林波.牛磺酸对内皮素生物学效应的机理探讨[J].河南大学学报（医学科学版）,2001,20(3):8-9. 被引量：5
-
10钱家庆.血管紧张素Ⅱ受体亚型及其阻断剂[J].中国药师,1999,2(5):240-241.
