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中国东部汉族人群原发性胆汁性肝硬化与HLA-DRB1相关性分析 被引量：3

Susceptibility of DRB1 alleles in the east of Chinese people with primary biliary cirrhosis
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摘要 目的:探讨组织相容性抗原Ⅱ类HLA-DRB1等位基因与原发性肝汁性肝硬化(Primarybiliarycirrhosis,PBC)患者人群的相关性。方法:采用序列特异性引物PCR(SSP-PCR)对105例确诊PBC患者,400例健康人群进行HLA-DRB1等位基因及相关亚型基因分析。结果:PBC患者组DRB1*07的频率为37·26%,与正常人组的13·8%相比存在显著性差异(P<0·05,比数比为2·7),所有阳性患者经亚型分析均为DRB1*0701;其余DRB1的等位基因频率与正常对照组比较无显著性差异。DRB1*0701阳性与阴性患者群体的疾病进程、临床指征、实验室指征等无显著性差异。结论:中国人群PBC患者可能与DRB1*0701易感性相关,为临床治疗提供了一定线索。 Objective ：To study the susceptibility of HLA-DRB1 alleles in patients with primary biliary cirrhosis（PbC）. Methods：Sequence specific primary polymerase chain high-resolution subtyping was applied. The susceptibility was analyzed statistically by SPSS software. Results.The frequenee of DRB1 ＊ 07 was increased by 37.26% compared with 13. 8% in controls （ P 〈 0. 05 ,OR = 2. 7） while frequencies for the other DRB1 alleles showed no significance. Condusion：DRB1 ＊ 0701 allele is related to PBC in Chi- nese people,especially for the eastern region,which is helpful for diagnosis and research for PBC further.
作者 陈燕 周晔 邓安梅 陈波 蒋天舒 仲人前
机构地区 第二军医大学附属长征医院临床实验诊断科
出处 《中国免疫学杂志》 CAS CSCD 北大核心 2006年第12期1143-1145,共3页 Chinese Journal of Immunology
关键词 原发性胆汁性肝硬化(PBC) HLA-DRB1 序列特异性引物聚合酶链反应 Primary biliary eirrhosis（PBC） HLA-DRB1 SSP-PCR
分类号 R392-4 [医药卫生—免疫学]
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参考文献6

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二级参考文献1

  • 1文庆成，中华医学检验杂志，1982年，5期，221页

共引文献7

同被引文献50

  • 1姜小华,仲人前,方晓云,安峰,胡寅,孔宪涛.原发性胆汁性肝硬化与HLA—DRB1、DQB1等位基因的相关性研究[J].中华肝脏病杂志,2004,12(7):436-436. 被引量：8
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引证文献3

二级引证文献11

中国免疫学杂志
2006年 第12期

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