摘要
目的:探讨组织相容性抗原Ⅱ类HLA-DRB1等位基因与原发性肝汁性肝硬化(Primarybiliarycirrhosis,PBC)患者人群的相关性。方法:采用序列特异性引物PCR(SSP-PCR)对105例确诊PBC患者,400例健康人群进行HLA-DRB1等位基因及相关亚型基因分析。结果:PBC患者组DRB1*07的频率为37·26%,与正常人组的13·8%相比存在显著性差异(P<0·05,比数比为2·7),所有阳性患者经亚型分析均为DRB1*0701;其余DRB1的等位基因频率与正常对照组比较无显著性差异。DRB1*0701阳性与阴性患者群体的疾病进程、临床指征、实验室指征等无显著性差异。结论:中国人群PBC患者可能与DRB1*0701易感性相关,为临床治疗提供了一定线索。
Objective :To study the susceptibility of HLA-DRB1 alleles in patients with primary biliary cirrhosis(PbC). Methods:Sequence specific primary polymerase chain high-resolution subtyping was applied. The susceptibility was analyzed statistically by SPSS software. Results.The frequenee of DRB1 * 07 was increased by 37.26% compared with 13. 8% in controls ( P 〈 0. 05 ,OR = 2. 7) while frequencies for the other DRB1 alleles showed no significance. Condusion:DRB1 * 0701 allele is related to PBC in Chi- nese people,especially for the eastern region,which is helpful for diagnosis and research for PBC further.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2006年第12期1143-1145,共3页
Chinese Journal of Immunology