摘要
目的：了解bmi-1基因编码蛋白在卵巢肿瘤中的表达情况，为阐明卵巢肿瘤发生的分之机理提供依据。方法：选择我校附属医院病理科2000—2006年的患者切片，包括浆液性囊腺癌27例、粘液性囊腺癌29例、恶性宫内膜样癌28例、卵巢良性肿瘤10例，正常卵巢标本10例。免疫组化法测bmi-1蛋白。结果：（1）不同分化程度的三种肿瘤的与正常卵巢及卵巢良性肿瘤比较，bmi-1蛋白呈过表达（P〈0．05）；（2）进一步作关联性分析，浆液性囊腺癌、粘液性囊腺癌、恶性宫内膜样癌的肿瘤细胞分化程度与bmi-1表达程度之间无关联性。结论：bmi-1基因的过表达在卵巢肿瘤的发生中有重要愿意。
Objective： In order to explore the mechanism of ovary tumor, the expression of bmi - 1 protien was tested in this study. Methods：Tbe specimens were obtained by the doctors who worked in the pathology department of our hospital during 2000 to 2006. Bmi - 1 protien expression in ovarian serous Cystadenocarcinoma （ n = 27 ）, mucinous Cystadenocarcinoma; （n =28） , endometrioid carcinoma, benign tumor（ n = 10） , and normal tissue（ n = 10） were tested by means of immunohistochemistry. Results： （1） Bmi -1 protien was over expression in the three kinds of ovarian tumor; （2） Correlation analysis showed that there were no correlation relationship between the expression of bmi - 1 and the degree of the malignant cell. Conclusion：The over expression of bmi - 1 gine played an important role in the development of ovarian tumor.
出处
《牡丹江医学院学报》
2006年第6期6-8,共3页
Journal of Mudanjiang Medical University
