氟伐他汀调脂治疗对血管内皮功能的影响

The Effect of Cholesterol-lowing Therapy with Fluvastatin on Endothelial Function of Vessel

目的：探讨高脂血症患者血管内皮细胞功能的变化及氟伐他汀对其的影响。方法：选高脂血症患者44例为治疗组，血脂正常者20例为对照组，检测氟伐他汀治疗前后血浆内皮素-1浓度（ET-1）和血脂，观察肱动脉血管超声检测血管内皮依赖性舒张功能的变化。结果：高脂血症组ET-1的水平明显高于对照组（P〈0．01），血管内皮依赖性舒张显著低于对照组（P〈0．01）；氟伐他汀治疗后1周血脂水平较治疗前有下降趋势，但无统计学意义（P〉0．05），而ET-1明显下降、反应性充血引起的肱动脉内径扩张显著增强（P〈0．05）；治疗后8周TC、TG、LDL-C均有明显降低（P〈0．05～0．01），且ET-1进一步降低，反应性充血引起的肱动脉内径扩张进一步增强（P〈0．01）。结论：高脂血症患者内皮功能受损，氟伐他汀调脂治疗的同时具有改善内皮功能的作用。

Objective： To investigate endothelial function change of vessel in patients with hypereholesterolemia and the effect of fluvastatin on it. Method： forty-four patients with hypereholesterolemia were selected as therapy group and twenty patients with ortholiposis as control group. Serum endothelin-1 （ET-1） content, blood lipid were measured, and changes of endothelium-dependent relaxing function were observed before and after the treatment of fluvastatin. Results： Compared with the control group, serum ET-1 and endothelium-dependent relaxing function were significantly higher before treatment（P 〈0.01 ） ; After cholesterol-lowing therapy with fluvastatin for one week, the serum ET-1 were lowered from 75.09±6.10pg/L to 68.08 ± 10.24 pg/L （P 〈0.05） and endothelium-dependent relexing function were significantly improved （ P 〈 0.05） . By the end of the 8th week, TC, TG, and LDL-C were significantly lower（ P 〈 0.05, of P 〈 0.01 ）, the serum ET-1 further decreased, and endothelium-dependent relexing function further improved（ P 〈 0.05 ）than those before the treatment. Conclusions： Endothelial function of vessel in patients was impaired by hypereholesterolemia, and fluvastatin may improve endothelial function of vessel.