摘要
采用扫描电子显微镜、X射线衍射法和红外光谱在草酸钙(CaOxa)结石患者尿液中研究了从海带中提取的硫酸多糖(LSPS)的防石作用。结果表明,LSPS可以抑制一水草酸钙(COM)的成核和聚集,并诱导二水草酸钙(COD)晶体形成。随着ESPS浓度从0增加到0.005,0.02和0.20 mg/m l,COD的百分含量从0分别增加到22%,55%和100%。这些结果表明LSPS是抑制CaOxa结石形成的一种潜在药物。
The inhibition of calcium oxalate （CaOxa） urinary stone by sulfated polysaccharide （LSPS） isolated from marine algae Laminarin was investigated in lithogenic urine by means of scanning electron microscopy, X-ray diffraction, and Fourier transform infrared spectroscopy. LSPS can inhibit the nucleation and aggregation of calcium oxalate monohydrate （COM） crystals, and induce the formation of calcium oxalate dihydrate （COD） crystals. With the concentration of LSPS increases from 0 to 0. 005, 0.02 and 0. 20 mg/mL, the percentage of COD crystals increased from 0 to 22%, 55% and 100%, respectively. It indicated that LSPS maybe a potential inhibitor to CaOxa urinary stones.
出处
《人工晶体学报》
EI
CAS
CSCD
北大核心
2006年第6期1296-1300,共5页
Journal of Synthetic Crystals
基金
Project supported by the Key Project of Guangdong Province(2006 B 36501001)and the National Natural Science Foundation ofChina(No.20471024)
关键词
草酸钙
硫酸多糖
尿结石
生物矿化
calcium oxalate
sulfated polysaccharid
urinary stone
biomineralization
