多枚药物洗脱支架治疗冠心病远期疗效

Long-term outcome of multi-drug-eluting stent implantation in patients with coronary artery disease

目的回顾性分析经皮冠状动脉介入治疗(PCI)患者植入单枚与多枚(≥3枚)药物洗脱支架远期预后差异。方法466例接受PCI治疗并植入药物洗脱支架患者,分为单个药物洗脱支架组(373例)和多枚药物洗脱支架组(93例)。比较两组的基础临床情况和12个月主要心脏不良事件(死亡、心肌梗死、靶血管血运重建)。结果与单枚药物洗脱支架组相比,多枚药物洗脱支架组有更多患者伴有高血压、糖尿病和心功能不良,随访17个月主要心脏不良事件发生率(17.2%)较单个药物洗脱支架组(8.6%)明显增加(P＜0.05)。结论与植入单个药物洗脱支架患者比较,植入多个药物洗脱支架患者远期预后不佳。

Objective To assess long-term outcome in patients with 33 coronary artery drug-eluting stents implantation via PCI, retrospectively. Methods Four hundreds and sixty-six patients with drug-eluting stent implantation via PCI were divided into one stent implantation （group A, n=373）and ≥3 drug-eluting stents implantation （group B, n = 93）. Basic clinical characteristics were recorded and the major adverse cardiac events （death, MI, target vessel revascularization）were documented during at least 12 months follow-up after successful percutaneous coronary intervention. Results Patients in group B had more hypertension, diabetes mellitus and poor cardiac function than those in group A. Group B showed more major adverse cardiac events than those of group A during an average of 17 months follow-up, 17.2% versus 8.6% respectively, （P 〈 0.05）. Conclusions Long-term outcome in patients with ≥ 3 drug-eluting stents implantation is poorer than that with only a single one.