兔盲肠结扎穿孔早期血液动力学改变及肺抗氧化作用的探讨

STUDY ON HAEMODYNAMIC CHANGES AND ANTIOXIDANT ACTION OF LUNG DURING EARLY STAGE AFTER RABBIT CECAL LIGATION AND PUNCTURE

实验采用乌拉坦麻醉家兔盲肠结扎穿孔（ＣＬＰ）模型，观察ＣＬＰ前后血液动力学变化及肺动脉氧化作用，结果发现兔ＣＬＰ后１～５ｈ平均动脉血压（ＭＡＰ）明显下降，而在２，２．５ｈ后出现肺动脉压（ＰＡＰ）明显升高。ＣＬＰ后２．５ｈ入肺血丙二醛（ＭＤＡ）比ＣＬＰ前明显增加，出肺血无显著改变；而出肺血超氧化物歧化酶（ＳＯＤ）比ＣＬＰ前者明显增高，入肺血无显著改变。结果提示兔盲肠结扎穿孔早期即有ＭＡＰ和ＰＡＰ的改变，在此过程中肺脏具有抗氧化作用。

Mean artery pressure(MAP), pulmonary artery pressure(PAP) were observed before and after rabbit cecal ligation and puncture(CLP). The contents of malondialdehyde(MDA) and superoxide dismutase(SOD) in-flowing and out-going pulmonary blood (IPB, OPB) were also determined. The results showed MAP decreased 1￣5 h after CLP, while PAP increased significantly 2, 2.5h after CLP. The content of MDA in IPB was increased but that in OPB had no change after CLP. In contrast, the content of SOD in OPB increased but that in IPB had no change.