红茂草注射液对免疫低下小鼠免疫功能的影响

Enhanced effect of Dicranostigma Leptopodum(Maxim.) Fedde on experimental immunosuppression in mice

研究红茂草注射液对小鼠实验性免疫功能低下的影响．以地塞米松(DEX,0．8 mg／kg)造成免疫功能低下的动物模型,用3个不同质量分数的红茂草注射液(50,100,200 mg／(kg·d)×4 d)分别予以治疗后,采用碳粒廓清法、溶血素测定法、器官指数测定等有关免疫指标．红茂草注射液可使小鼠的廓清指数K值、吞噬指数α值、器官指数、血清溶血素及溶菌酶活力增高,尤以100 mg／kg剂量组效果显著．红茂草注射液对实验性免疫功能低下小鼠有明显的免疫增强作用,这为其应用于临床治疗提供了一定的实验依据．

The effects of Dicranostigma Leptopodum （Maxim.） Fedde on experimental immunosuppression were studied in mice. The immunologic inadequacy model was induced by dexamethasone （DEX, 0.8 mg/kg, ip）.The immunomodulatory effects of the drug were measured by the cleaning carbon particle method, hemolysin determine assay and organ index assay. The DLF could increase the level of serum hemolysin. K and a values were markely increased by DLF injection solution （100 mg/（kg·d）, ip）. The drug could also enhance yhe organ index. In addition, the drug could increase the lysozyme level in serum and DLF has had a enhanced effect on experimental immunosuppression in mice.