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NKT细胞抗肿瘤作用及其机制 被引量：2

The Anti-tumor Role and Mechanisms of Natural Killer T Cells
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摘要 自然杀伤T细胞(NKT)是一类特殊类型的T淋巴细胞,可识别由CD1d分子提呈的抗原,活化后既可直接作为抗肿瘤效应细胞发挥杀伤作用,又能通过激活其他免疫效应细胞,如NK细胞,间接实现抗肿瘤作用.NKT细胞在机体的自身免疫性疾病、感染性疾病、肿瘤以及移植排斥等方面也发挥着重要的作用. NKT cells are an unique T lymphocyte sub -lineage and can recognize glycolipids presented by CDld molecules through cell recognition pathway. After activated, NKT cells can kill tumors directly as the anti - tumor effectors and they can also activate other cell types such as NK cells, which can mediate anti - tumor effects indirectly. NKT cells also play an important role in autoimmune disease, infectious diseases, cancer and transplantation rejection.
作者 夏洪颖 刘旭
机构地区 昆明医学院云南省天然药物药理重点实验室
出处 《昆明医学院学报》 2006年第6期104-107,共4页 Journal of Kunming Medical College
基金 教育部科学技术研究重点项目资助(03125) 云南省教育厅科研基金重点项目资助(02ZD259)
关键词 NKT细胞 肿瘤 IL-12 a-GalCer NKT cells Cancer IL - 12 a - Galcer
分类号 R392.12 [医药卫生—免疫学]
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参考文献19

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二级参考文献10

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共引文献1

同被引文献41

  • 1史艳侠,张晓实,刘冬耕,管忠震,姜文奇.CD8^+CD28^-Ts、CD3^+CD56+NKT细胞在B细胞非霍奇金淋巴瘤患者外周血中分布的分析[J].癌症,2004,23(z1):1437-1442. 被引量：4
  • 2刘敏,孔北华,曲迅.卵巢肿瘤患者外周血NK细胞受体NKG2A、NKG2D及NK活性检测的临床意义[J].现代免疫学,2005,25(3):239-241. 被引量：8
  • 3冯伟华,蔡蓓,王兰兰,陈捷.CD_3^+CD_(56)^+NKT细胞及CD_3^-CD_(56)^+NK细胞在恶性肿瘤患者的临床意义研究[J].中国肺癌杂志,2007,10(5):429-432. 被引量：17
  • 4Zhao J, Weng X, Bagchi S, et al. Polyclonal type I! natural killer T ceils require PLZF and SAP for their development and contribute to CpG-mediated antitumor response [ J ]. Proc Natl Acad Sci U S A, 2014, 111 (7) : 2674-2679.
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引证文献2

二级引证文献5

昆明医学院学报
2006年 第6期

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