乳腺癌nm23-H1表达的临床意义

Clinical significance of nm23-H1 protein′s expression in breast carcinoma

目的:研究nm23-H1蛋白在乳腺癌中表达的临床意义及其与C-erbB-2蛋白表达的关系。方法:应用免疫组化法对87例乳腺癌患者标本中nm23-H1、C-erbB-2蛋白的表达进行检测。结果:nm23-H1蛋白阳性表达率为51.72%(45/87),与淋巴结状态、组织学分级、临床分期及术后生存期有关;与年龄、肿瘤大小无明显关系。与C-erbB-2蛋白的表达呈负相关。结论:nm23-H1的表达可能与乳腺癌的发展及预后有关;nm23-H1与C-erbB-2蛋白的表达呈负相关。nm23-H1蛋白的表达对判断乳腺癌进展及预后有一定的参考价值。

Objective： To investigate the clinical significance of nm23-H1 protein＇s expression in breast carcinoma and the relationship between the expression of nm23-H1 and C-erbB-2 protein. Methods： The expression of nm23-H1 protein and C-erbB-2 protein in 87 samples of breast carcinoma was determined by immunohistochemical technique. Results： Positive expression rate of nm23-H1 protein was51.72% （45/ 87 ） in the samples of breast carcinoma. There was significant relationship between the expression of nm23- H1 protein and the status of lymph node, histological grading, clinical stages and postoperative survive. There was not relationship between the expression of nm23-H1 protein and age, neither was the size of tumor. There was a reverse relationship between the expression of nm23-H1 and C-erbB-2 protein. Conclusion： The expression of nm23-H1 protein was probably associated with the development and postoperative survive of breast carcinoma. The expression of nm23-H1 may be taken as one of the prognosis factors.