胰岛素泵治疗糖尿病酮症临床探讨

Clinical Study of Insulin Pump Therapy in Diabetes Ketoacidosis

【目的】探讨胰岛素泵治疗糖尿病酮症(DK)的临床疗效。【方法】70例DK病人随机分为皮下胰岛素泵治疗组(CSII组)和常规小剂量胰岛素静脉滴注治疗组(对照组)各35例,两组年龄、血糖和体重指数(BMI)相比无显著性差异。观察两种不同给药方法患者血糖、尿酮体的变化,胰岛素用量差异及低血糖发生率。【结果】CSII组与对照组血糖水平均显著降低,患者的血糖经治疗达目标血糖值的时间相似(P>0.05),但CSII组较对照组尿酮体转阴时间明显缩短(P<0.01),胰岛素用量减少(P<0.01),低血糖发生频率低。【结论】胰岛素泵是一种更安全、更快、更有效、更方便,值得推广的DK治疗方法。

[Objective]To research the clinical curative effect of continuous subcutaneous infusion with insulin pump on diabetic ketoacidosis（DK）, [MethodslSeventy patients with DK were divided into two groups with 35 cases in each： insulin pump treated group（CSII group） and low dose intravenous infusion treated group （control group）. Patients in two groups were matched in age, blood glucose and BMI（P〉0.05）. The average recovering time of blood glucose, the dosages of insulin, urinary ketoacidosis and the frequency of hypoglycemia incidence were observed in two groups. [Results]Two groups could evidently reduce the level of glycemia. The level of blood glucose control in two groups was similar after treatment（ P 〉0.05）. But to compare with the regular continuous insulin injection, the insulin pump therapy had advantage of decreasing the insulin dosages（ P〈0.01） ,shortening the disappeared days Of ketone body（ P〈0.01）, decreasing the frequency of hypoglycemia. [Conclusion]The treatment of insulin pump is safer, quicker,more effective and expedient than intravenous insulin infusion in patients with DK, and it is recommendable.