氟烷基碘与乙烯基乙醚和胺一锅法反应合成氟烷基烯胺酮

One-Pot Reaction of Fluoralkyl Iodide with Ethyl Vinyl Ether and Amines to Synthesize Fluoroalkylenaminoketones

研究了在保险粉存在下，氟烷基碘（1）与乙烯基乙醚和伯胺或仲胺（2）的反应。在40～50℃下，反应主要生成相应的氟烷基烯胺酮（3）。2-氯-1，1，2，2-四氟乙基碘或2-溴-1，1，2，2-四氟乙基碘在回流条件下反应则分别生成氢化脱氯或脱溴的氟烷基烯胺酮（4），但对于长氟碳链的4-氯-1，1，2，2，3，3，4，4-八氟丁基碘，未见有脱氯产物生成。

The reaction of fluoroalkyl iodides with ethyl vinyl ether and amines in the presence of sodium dithionite was studied. Fluoroalkylenaminoketones were obtained when the reaction was carried out at 40～50 ℃. Under reflux, dechlorinating or debrominating products, ω-hydro-fluoroalkylenamino-ketones, were formed in cases of ω-chloro-1,1,2,2-tetrafluoroethyl iodide and ω-bromo 1,1,2,2-tetrafluoroethyl iodide. However, no corresponding dechlorinating product was produced for long-chain 4-chloro- 1,1,2,2,3,3,4,4-octafluorobutyl iodide.